# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150320: node_PTN000274640 has function cysteine-type endopeptidase activity (GO:0004197) 20150320: Eukaryota_PTN001391516 has function cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656) 20150320: Eumetazoa_PTN001391531 has function aminopeptidase activity (GO:0004177) 20150320: Amoebozoa_PTN000964173 has LOST/MODIFIED function cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656) 20150320: Bilateria_PTN000274687 has LOST/MODIFIED function cysteine-type endopeptidase activity (GO:0004197) # cellular_component 20150320: node_PTN000274640 is found in lysosome (GO:0005764) 20150320: node_PTN000274640 is found in extracellular space (GO:0005615) 20150320: Bilateria_PTN000274687 is NOT found in lysosome (GO:0005764) 20150320: Euryarchaeota_PTN000964623 is NOT found in lysosome (GO:0005764) 20150320: Bacteria _PTN000275629 is NOT found in lysosome (GO:0005764) # biological_process 20150320: node_PTN000274640 participates in proteolysis involved in cellular protein catabolic process (GO:0051603) 20150320: Eukaryota_PTN000749203 participates in immune response (GO:0006955) 20150320: Eukaryota_PTN001391516 participates in positive regulation of apoptotic signaling pathway (GO:2001235) 20150320: Eukaryota_PTN001391516 participates in positive regulation of peptidase activity (GO:0010952) 20150320: Bilateria_PTN000274687 participates in cell adhesion (GO:0007155) 20150320: Euteleostomi_PTN000274922 participates in basement membrane disassembly (GO:0034769) 20150320: Euteleostomi_PTN000274922 participates in immune response (GO:0006955) 20150320: Euteleostomi_PTN000274922 participates in antigen processing and presentation (GO:0019882) 20150320: Eukaryota_PTN000964528 participates in immune response (GO:0006955) 20150320: Amoebozoa_PTN000964173 does NOT participate in positive regulation of apoptotic signaling pathway (GO:2001235) 20150320: Amoebozoa_PTN000964173 does NOT participate in positive regulation of peptidase activity (GO:0010952) 20150320: Bilateria_PTN000274687 does NOT participate in proteolysis involved in cellular protein catabolic process (GO:0051603) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).