# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
15 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140827: root_PTN000250728 has function 5'-nucleotidase activity (GO:0008253) 

# cellular_component

# biological_process
20140827: Euteleostomi_PTN000250754 participates in adenosine metabolic process (GO:0046085) 
20140827: Euteleostomi_PTN000250754 participates in IMP metabolic process (GO:0046040) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Molecular function - although there are only two genes annotated with term 5'-nucleotidase activity (GO:0008253), the MSA are highly conserved with the nuceotidase domain. It is very likely that the function is conserved. Therefore, propagate the term to the root.
Cellular component - The mitochondria annotation to the mouse gene is from HTP experiment.
Biological process - the adenosine and IMP metabolism are propagated only to the NT5C2 clade because it is not clear if the same process is conserved throughout the tree.
Aug. 27. 2014, HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).