# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20150306: cellular organisms_PTN000237328 is found in cytoplasmic exosome (RNase complex) (GO:0000177) 20150306: node_PTN000237329 is found in nuclear exosome (RNase complex) (GO:0000176) 20150306: node_PTN000237329 is found in nucleolus (GO:0005730) # biological_process 20150306: root_PTN000237327 participates in rRNA catabolic process (GO:0016075) 20150306: node_PTN000237329 participates in rRNA 3'-end processing (GO:0031125) 20150306: node_PTN000237329 participates in U4 snRNA 3'-end processing (GO:0034475) 20150306: node_PTN000237329 participates in polyadenylation-dependent snoRNA 3'-end processing (GO:0071051) 20150306: node_PTN000237329 participates in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' (GO:0034427) 20150306: node_PTN000237329 participates in nuclear mRNA surveillance (GO:0071028) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES These are all non-catalytic subunits in the exosome complex, so they do not have exonuclease activity, but they are still involved in the RNA processing process. 6-March-2015, HM # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).