# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
15 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150318: root_PTN000231993 contributes to function ubiquitin protein ligase activity (GO:0061630) 
20150811: root_PTN000231993 has function ubiquitin protein ligase binding (GO:0031625) 

# cellular_component
20150318: root_PTN000231993 is found in cullin-RING ubiquitin ligase complex (GO:0031461) 
20150318: Eukaryota_PTN000748578 is found in Cul4-RING E3 ubiquitin ligase complex (GO:0080008) 
20150318: Tetrapoda_PTN000232242 is found in Cul4A-RING E3 ubiquitin ligase complex (GO:0031464) 
20150318: Tetrapoda_PTN000232265 is found in Cul4B-RING E3 ubiquitin ligase complex (GO:0031465) 
20150318: Eukaryota_PTN000231994 is found in anaphase-promoting complex (GO:0005680) 
20150318: Opisthokonta_PTN000232059 is found in SCF ubiquitin ligase complex (GO:0019005) 
20150318: Eumetazoa_PTN000939848 is found in Cul2-RING ubiquitin ligase complex (GO:0031462) 
20150318: Eumetazoa_PTN000939877 is found in Cul5-RING ubiquitin ligase complex (GO:0031466) 

# biological_process
20150318: root_PTN000231993 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 
20150811: Eukaryota_PTN000232236 participates in cellular response to DNA damage stimulus (GO:0006974) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Reviews
https://en.wikipedia.org/wiki/Cullin
PMID: 25663940

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).