# HISTORY 24 Jan 2017: Saved by krc using Paint v2.29 on 24 Jan 2017 using PANTHER version UPL 11.0 # molecular_function 20170123: node_PTN000223361 has function dynein intermediate chain binding (GO:0045505) 20170123: node_PTN000223361 has function dynein light intermediate chain binding (GO:0051959) 20170123: node_PTN000223361 contributes to function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) 20170123: node_PTN000223361 has function cytoskeletal protein binding (GO:0008092) # cellular_component 20170123: Eukaryota_PTN000223362 is found in cytoplasmic dynein complex (GO:0005868) 20170123: node_PTN000223361 is found in dynein complex (GO:0030286) 20170123: Bilateria_PTN000934383 is found in myosin complex (GO:0016459) # biological_process 20170123: Ascomycota_PTN000223485 does NOT participate in intraciliary retrograde transport (GO:0035721) 20170123: node_PTN000223361 participates in positive regulation of ATP-dependent microtubule motor activity, plus-end-directed (GO:2000582) 20170123: Ascomycota_PTN000223485 does NOT participate in intraciliary retrograde transport (GO:0035721) 20170123: Ascomycota_PTN000223485 does NOT participate in cilium assembly (GO:0060271) 20170124: Eukaryota_PTN000223362 participates in transport along microtubule (GO:0010970) 20170124: Ascomycota_PTN000223485 does NOT participate in intraciliary retrograde transport (GO:0035721) 20170124: Ascomycota_PTN000223485 does NOT participate in cilium assembly (GO:0060271) 20170124: Eukaryota_PTN000223362 participates in cilium assembly (GO:0060271) 20170124: Eukaryota_PTN000223362 participates in transport along microtubule (GO:0010970) # PRUNED 23 Jan 2017: Vibrio cholerae O1 biovar El Tor str. N16961_VC_A0283 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This is a dynein light chain family, mostly of cytoplasmic dynein light chains. However, the node 9EUKA:PTN000223538 contains sequences for the axonemal DNAL4. I have left it here, even though it seems a little separate from the rest of the family since I can at least propagate some general dynein terms, if not anything specific to its role as an axonemal dynein since DNAL4 does not seem to be experimentally characterized in vertebrates. . Vertebrates have two genes for cytoplasmic dynein light chains, DYNLL1 and DYNLL2. Day et al suggest that DYNLL1 is found in the cytoplasmic dynein 2 complex that is involved in intraflagellar transport (IFT), while DYNLL2 is found in a myosin V complex. - Day CL et al. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J. 2004 Feb 1;377(Pt 3):597-605. PubMed PMID: 14561217 . Basic structure of tree to help understand where to make propagations: --------------------------------------------------------- 9ZZZZ:PTN002275528 (horizontal transfer node) - VIBCH:VC_A0283 - 9ZZZZ:PTN000223361 -- 9EUKA:PTN000223538: DNAL4 --- 9EUKA:PTN000223362 ---- 9EUKA:PTN000223363 ----- PTN000223364 ------ PTN000934381 ------- PTN000934382 -------- 9ZZZZ:PTN002275532 (dup node) --------- 9BILA:PTN000934383: DYNLL2 --------- 9BILA:PTN000223365 ---------- 9ZZZZ:PTN000934401 (dup node) ----------- PTN000223366: DYNLL1 ----------- PTN000934412: more vert dynll1 seqs & starfish Dynlc2 ---------- PTN000223464: Cel dlc-2 & dlc-5; Dmel ctp ---------- 9ZZZZ:PTN000934441: Schistosoma seqs ----- 9FUNG:PTN000934453: Sc DN2 ----- PTN000223494: 3 seqs, incl 1 Dicty ---- 9EUKA:PTN000934467: Plasmodium, Tetrahymena, & Phytophthora seqs ---- 9EUKA:PTN000934481: Leishmania, Trypanosoma, Giardia, & Trichomonal seqs ---- 9VIRI:PTN000223514: 2 Chlamy seqs + a large plant expansion # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).