# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151009: root_PTN000211184 has function metalloendopeptidase activity (GO:0004222) # cellular_component 20151009: Eukaryota_PTN000211186 is found in mitochondrion (GO:0005739) 20151009: Viridiplantae_PTN000211236 is found in chloroplast thylakoid membrane (GO:0009535) 20151009: Opisthokonta_PTN000211242 is found in mitochondrial intermembrane space (GO:0005758) 20151009: node_PTN001720503 is found in chloroplast (GO:0009507) 20151009: node_PTN000928330 is found in cytosol (GO:0005829) 20151009: Viridiplantae_PTN000211236 is NOT found in mitochondrion (GO:0005739) # biological_process 20151009: root_PTN000211184 participates in peptide metabolic process (GO:0006518) 20151009: Eukaryota_PTN000928390 participates in protein processing involved in protein targeting to mitochondrion (GO:0006627) 20151009: Bacteria _PTN000928338 participates in signal peptide processing (GO:0006465) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).