# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150605: Eukaryota_PTN000172316 has function protein kinase activity (GO:0004672) 20150605: Deuterostomia_PTN000684847 has function MAP kinase kinase kinase activity (GO:0004709) # PRUNED # cellular_component # biological_process 20150605: Deuterostomia_PTN000684847 participates in activation of MAPKK activity (GO:0000186) 20150605: Theria _PTN000684887 participates in intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631) 24 Mar 2016: Eukaryota_PTN000172175 has been pruned from tree 24 Mar 2016: Eukaryota_PTN001696988 has been pruned from tree 24 Mar 2016: Eukaryota_PTN001357828 has been pruned from tree 24 Mar 2016: Eukaryota_PTN001358094 has been pruned from tree 24 Mar 2016: Eukaryota_PTN001696995 has been pruned from tree 24 Mar 2016: node_PTN001696992 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED ## Annotations that have been removed. 20150605: Deuterostomia_PTN000684847 to cellular response to stress (GO:0033554) is an excluded term and not to be used for annotation # NOTES 14 Mar 2016: node_PTN001696992 has been pruned from tree 14 Mar 2016: Eukaryota_PTN001696995 has been pruned from tree 14 Mar 2016: Eukaryota_PTN000172175 has been pruned from tree 14 Mar 2016: Eukaryota_PTN001696988 has been pruned from tree 14 Mar 2016: Eukaryota_PTN001357828 has been pruned from tree 14 Mar 2016: Eukaryota_PTN001358094 has been pruned from tree # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).