# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150911: Metazoa_PTN001665142 has function chemorepellent activity (GO:0045499) 
20150910: Metazoa_PTN001665142 has function semaphorin receptor binding (GO:0030215) 
20150914: node_PTN000867406 has function neuropilin binding (GO:0038191) 
20150910: Tetrapoda_PTN000867403 has function integrin binding (GO:0005178) 
20150914: Euteleostomi_PTN000112729 has LOST/MODIFIED function neuropilin binding (GO:0038191) 
20150914: Euteleostomi_PTN001336910 has LOST/MODIFIED function neuropilin binding (GO:0038191) 
20150914: Euteleostomi_PTN000709529 has LOST/MODIFIED function neuropilin binding (GO:0038191) 
20150911: Tetrapoda_PTN000867403 has LOST/MODIFIED function chemorepellent activity (GO:0045499) 
20150910: Tetrapoda_PTN000867403 has LOST/MODIFIED function semaphorin receptor binding (GO:0030215) 
20150914: Euteleostomi_PTN000112375 has LOST/MODIFIED function neuropilin binding (GO:0038191) 
20150914: Euteleostomi_PTN000112914 has LOST/MODIFIED function neuropilin binding (GO:0038191) 

# cellular_component
20150910: Bilateria_PTN000744245 is found in extracellular space (GO:0005615) 
20150910: node_PTN000112730 is found in plasma membrane (GO:0005886) 
20150910: Tetrapoda_PTN000112752 is found in membrane (GO:0016020) 
20150910: Euteleostomi_PTN000112375 is found in plasma membrane (GO:0005886) 
20150910: Euteleostomi_PTN001336910 is found in plasma membrane (GO:0005886) 
20151008: Tetrapoda_PTN000867403 is found in external side of plasma membrane (GO:0009897) 
20150910: Tetrapoda_PTN000112586 is found in axon (GO:0030424) 
20150910: Bilateria_PTN001665210 is found in integral component of plasma membrane (GO:0005887) 
20150910: Bilateria_PTN000112938 is found in integral component of membrane (GO:0016021) 
20150910: Tetrapoda_PTN000867403 is NOT found in extracellular space (GO:0005615) 
20150910: Teleostei_PTN000867408 is NOT found in extracellular space (GO:0005615) 

# biological_process
20150911: Metazoa_PTN001665142 participates in neural crest cell migration (GO:0001755) 
20150910: Metazoa_PTN001665142 participates in semaphorin-plexin signaling pathway (GO:0071526) 
20150911: Metazoa_PTN001665142 participates in positive regulation of cell migration (GO:0030335) 
20150910: Metazoa_PTN001665142 participates in negative regulation of axon extension involved in axon guidance (GO:0048843) 
20150911: Bilateria_PTN000744245 participates in negative chemotaxis (GO:0050919) 
20150911: Tetrapoda_PTN000867403 participates in regulation of inflammatory response (GO:0050727) 
20150911: Tetrapoda_PTN000867403 participates in positive regulation of axon extension (GO:0045773) 
20150911: Tetrapoda_PTN000867403 participates in positive regulation of ERK1 and ERK2 cascade (GO:0070374) 
20150911: Tetrapoda_PTN000867403 participates in positive regulation of macrophage cytokine production (GO:0060907) 
20150911: Tetrapoda_PTN000867403 participates in integrin-mediated signaling pathway (GO:0007229) 
20150911: Tetrapoda_PTN000112586 participates in positive regulation of neuron migration (GO:2001224) 
20150911: Euteleostomi_PTN000112672 participates in positive regulation of neuron migration (GO:2001224) 
20150911: Tetrapoda_PTN000867403 does NOT participate in negative chemotaxis (GO:0050919) 
20150910: Tetrapoda_PTN000867403 does NOT participate in semaphorin-plexin signaling pathway (GO:0071526) 
20150910: Tetrapoda_PTN000867403 does NOT participate in negative regulation of axon extension involved in axon guidance (GO:0048843) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).