# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140605: node_PTN001333813 has function microtubule binding (GO:0008017) # cellular_component 20140605: Fungi_PTN000861115 is found in fungal-type vacuole membrane (GO:0000329) 20140605: node_PTN000103525 is found in autophagosome membrane (GO:0000421) 20140605: node_PTN000103525 is found in cytosol (GO:0005829) # biological_process 20140605: Eukaryota_PTN000103522 participates in cellular response to nitrogen starvation (GO:0006995) 20140605: node_PTN000103525 participates in mitophagy (GO:0000422) 20140605: node_PTN000103525 participates in autophagosome assembly (GO:0000045) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES ATG8 is a ubiquitin-like protein that is lipidated by phosphatidyl ethanolamine which targets it to the pre-autophagosomal membrane. It is required for membrane fusion. PG-MAF 2014-06-11 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).