# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20160108: Bilateria_PTN000103178 has function beta-amyloid binding (GO:0001540) # cellular_component 20160108: Bilateria_PTN000103178 is found in plasma membrane (GO:0005886) 20160108: Bilateria_PTN000103178 is found in Golgi apparatus (GO:0005794) 20160108: Bilateria_PTN000103178 is found in extracellular exosome (GO:0070062) # biological_process 20160108: Bilateria_PTN000103178 participates in negative regulation of amyloid precursor protein biosynthetic process (GO:0042985) 20160108: Bilateria_PTN000103178 participates in nervous system development (GO:0007399) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).