# HISTORY 05 Oct 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161005: Eukaryota_PTN000089417 has function squalene monooxygenase activity (GO:0004506) # cellular_component 20161005: Eukaryota_PTN000089417 is found in endoplasmic reticulum (GO:0005783) # biological_process 20161005: Fungi_PTN000851137 participates in ergosterol biosynthetic process (GO:0006696) 20161005: Eukaryota_PTN000089417 participates in sterol biosynthetic process (GO:0016126) 20161005: Eumetazoa_PTN002247263 participates in cholesterol metabolic process (GO:0008203) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).