# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20110201: node_PTN000082845 has function serine-type endopeptidase activity (GO:0004252) # cellular_component 20110201: Bilateria_PTN000082858 is found in extracellular space (GO:0005615) 20110201: Euteleostomi_PTN000082961 is found in extracellular space (GO:0005615) 20110201: Deuterostomia_PTN000082930 is found in extracellular space (GO:0005615) 20110201: node_PTN000083124 is found in cell wall (GO:0005618) # biological_process 20110201: Eukaryota_PTN000083315 participates in proteolysis (GO:0006508) 20110201: Opisthokonta_PTN000082856 participates in protein processing (GO:0016485) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF Propagted GO:8236, Serine type endopeptidase activity to AN0. CC Propaged GO: 5615 extracellular space, GO:5794 Golgi apparatus in some cases. GO: 5619, ascopore wall was propagated through AN631, because the node contains all fungal proteins and this is a valid component term for that family. MF GO:6508, proteolysis or GO: 1605 protein maturation by peptide bond cleavage were propageted to most proteins. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).