# HISTORY 17 Jan 2017: Saved by pgaudet using Paint v2.29 on 17 Jan 2017 using PANTHER version 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20170117: root_PTN000078673 has function glycine-tRNA ligase activity (GO:0004820) 20170117: Metazoa_PTN001644197 has function DNA-directed DNA polymerase activity (GO:0003887) 20170117: Metazoa_PTN001644197 has LOST/MODIFIED function glycine-tRNA ligase activity (GO:0004820) # cellular_component 20170117: Metazoa_PTN001644197 is found in gamma DNA polymerase complex (GO:0005760) 20170117: root_PTN000078673 is found in cytoplasm (GO:0005737) 20170117: Eukaryota_PTN000078675 is found in mitochondrion (GO:0005739) # biological_process 20170117: Metazoa_PTN001644197 participates in mitochondrial DNA replication (GO:0006264) 20170117: root_PTN000078673 participates in glycyl-tRNA aminoacylation (GO:0006426) 20170117: Eukaryota_PTN000078675 participates in mitochondrial glycyl-tRNA aminoacylation (GO:0070150) 20170117: Metazoa_PTN001644197 does NOT participate in mitochondrial glycyl-tRNA aminoacylation (GO:0070150) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).