# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140922: Bilateria_PTN001098750 has function epidermal growth factor receptor binding (GO:0005154) 
20140922: Bilateria_PTN001098750 has function growth factor activity (GO:0008083) 
20140922: Amniota_PTN000077739 has function heparin binding (GO:0008201) 

# cellular_component
20140922: Bilateria_PTN001098750 is found in extracellular space (GO:0005615) 
20140922: Euteleostomi_PTN000077766 is found in integral component of plasma membrane (GO:0005887) 
20140922: Amniota_PTN000077739 is found in integral component of plasma membrane (GO:0005887) 

# biological_process
20140922: Bilateria_PTN001098750 participates in positive regulation of cell proliferation (GO:0008284) 
20140922: Bilateria_PTN001098750 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 
20140922: Euteleostomi_PTN000077766 participates in activation of MAPK activity (GO:0000187) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
BP- most of them are indirect, so they are not propagated. Positive regulation of cell proliferation is also indirect, but it is so closely related to EGFR signaling process, the term was propagated.
MF - The MAP kinase kinase activity seems to be wrong. The gene doesn't have the kinase activity. The reference shows that when the cell is cultured with the protein, the phosphorylated form of MAP kinase increases.
Sept. 22 2014, HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).