# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20110201: Eukaryota_PTN000070561 has function ARF guanyl-nucleotide exchange factor activity (GO:0005086) 

# cellular_component
20120409: Eukaryota_PTN000070561 is found in trans-Golgi network (GO:0005802) 
20120409: Magnoliophyta_PTN000071184 is found in cytosol (GO:0005829) 

# biological_process
20120409: Eukaryota_PTN000070561 participates in vesicle-mediated transport (GO:0016192) 
20120409: Bilateria_PTN000070822 participates in actin cytoskeleton organization (GO:0030036) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
CC
Propagated trans-Golgi network to root because this is widely distributed and appears to be ancestral.  This appears to have been lost in the CYTH clade, which has instead many annotations to cytosol and plasma membrane.  Similarly in the IQSEC clade the proteins are localized to the nucleus and cell junction, and in the PSD (post synaptic density) clade to the cell junction.
BP
For the most part they are involved in vesicle-mediated transport (consistent with the widepread Golgi annotations) so annotated this to the root, and the cytohesin clade are involved in adhesion, the Mon2 clade in cytoskeletal organization, PSD to neuronal differentiation, IQSEC to cytoskeletal organization.  Annotated a loss of vesicle-mediated transport for the clades in which Golgi location is inferred to be lost.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).