# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20140828: Euteleostomi_PTN000068768 has function transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191) # cellular_component 20140828: Eumetazoa_PTN000837813 is found in nuclear aryl hydrocarbon receptor complex (GO:0034753) 20140828: Euteleostomi_PTN000068768 is NOT found in nuclear aryl hydrocarbon receptor complex (GO:0034753) # biological_process 20140828: Eumetazoa_PTN000837813 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20140828: Eumetazoa_PTN000837813 participates in response to xenobiotic stimulus (GO:0009410) 20140828: Euteleostomi_PTN000068768 does NOT participate in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The AHRR form is an inhibitor that represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes (see UniProt entry A9YTQ3). The cytoplasmic form of the complex is inactive. Upon ligand binding, its NLS is exposed and translocates to the nucleus, where it is active, so I did not propagate 'cytoplasm'. See http://en.wikipedia.org/wiki/Aryl_hydrocarbon_receptor PG 2014-08-28 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).