# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.12 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20110126: root_PTN000054102 has function FK506 binding (GO:0005528) 20110126: root_PTN000054102 has function peptidyl-prolyl cis-trans isomerase activity (GO:0003755) # cellular_component 20140604: root_PTN000054102 is found in cytoplasm (GO:0005737) 20140604: node_PTN000054497 is found in endoplasmic reticulum membrane (GO:0005789) 20140604: Amniota_PTN001314565 is found in sarcoplasmic reticulum membrane (GO:0033017) # biological_process 20140604: root_PTN000054102 participates in chaperone-mediated protein folding (GO:0061077) 20140604: Amniota_PTN001314565 participates in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MSL Fast-pass curation 2011-02-11 PG Reviewed family 2014-06-04 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).