# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20150716: node_PTN000705258 has function alanine dehydrogenase activity (GO:0000286) 20150716: node_PTN000017743 has function NAD(P)+ transhydrogenase (AB-specific) activity (GO:0008750) 20150716: node_PTN000017743 has function NADP binding (GO:0050661) 20150716: node_PTN000017743 has function NAD binding (GO:0051287) # cellular_component 20150716: node_PTN000705258 is found in plasma membrane (GO:0005886) 20150716: node_PTN001605925 is found in plasma membrane (GO:0005886) 20150716: Eukaryota_PTN000017744 is found in mitochondrial inner membrane (GO:0005743) 20150716: Bacteria _PTN001605934 is found in plasma membrane (GO:0005886) # biological_process 20150716: node_PTN000705258 participates in alanine catabolic process (GO:0006524) 20150716: node_PTN000017743 participates in NADPH regeneration (GO:0006740) 20150716: node_PTN000017743 participates in proton transport (GO:0015992) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).