# molecular_function
20160304: LUCA_PTN000011605 has function potassium:proton antiporter activity (GO:0015386)
20160304: LUCA_PTN000011605 has function sodium:proton antiporter activity (GO:0015385)
# cellular_component
20160304: Euteleostomi_PTN001298015 located in apical plasma membrane (GO:0016324)
20160304: Euteleostomi_PTN001298015 located in brush border membrane (GO:0031526)
20160304: Fungi_PTN000803809 located in late endosome (GO:0005770)
20160304: Fungi_PTN000803809 located in early endosome (GO:0005769)
20160304: Fungi_PTN000803809 lost/modified plasma membrane (GO:0005886) capacity
20160304: Fungi_PTN000803809 located in fungal-type vacuole membrane (GO:0000329)
20160304: Embryophyta_PTN000803979 located in chloroplast envelope (GO:0009941)
20160304: Bilateria_PTN000011723 lost/modified plasma membrane (GO:0005886) capacity
20160304: Bilateria_PTN000011723 located in Golgi apparatus (GO:0005794)
20160304: Opisthokonta_PTN000803768 located in recycling endosome (GO:0055037)
20160304: Viridiplantae_PTN000011943 located in endosome (GO:0005768)
20160304: Magnoliophyta_PTN000011934 located in vacuolar membrane (GO:0005774)
20160304: LUCA_PTN000011605 located in plasma membrane (GO:0005886)
# biological_process
20160304: Pentapetalae_PTN001603945 participates in regulation of stomatal closure (GO:0090333)
20160304: Fungi_PTN000803809 participates in vacuolar acidification (GO:0007035)
20160304: Fungi_PTN000803809 lost/modified sodium ion import across plasma membrane (GO:0098719) capacity
20160304: Bilateria_PTN000011723 lost/modified sodium ion import across plasma membrane (GO:0098719) capacity
20160304: LUCA_PTN000011605 participates in sodium ion import across plasma membrane (GO:0098719)
20160304: LUCA_PTN000011605 participates in regulation of intracellular pH (GO:0051453)
20160304: LUCA_PTN000011605 participates in potassium ion transmembrane transport (GO:0071805)
20160304: LUCA_PTN000011605 participates in sodium ion transmembrane transport (GO:0035725)
# Notes



Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).