# HISTORY 23 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20141113: root_PTN000007197 has function hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) 20141113: Opisthokonta_PTN000007257 has function beta-glucuronidase activity (GO:0004566) 20141113: node_PTN000007198 has function beta-mannosidase activity (GO:0004567) # cellular_component 20141113: root_PTN000007197 is found in intracellular membrane-bounded organelle (GO:0043231) # biological_process 20141113: root_PTN000007197 participates in carbohydrate metabolic process (GO:0005975) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The family name of 'beta galactosidase' is not correct. The family contains mainly beta mannosidase and beta glucuronidase. There are a few prokaryotic beta galactosidase at the bottom of the tree. Nov.13, 2014 - HM # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).