CHEK1
label: CHK1
label: UniProt:O14757 CHEK1

CDS1
label: CHEK2
label: CHK2
label: RAD53
label: UniProt:O96017-12 CHEK2

ATM
label: UniProt:Q13315 ATM

Phosphorylation of Cdc25A at Ser-123 in response to DNA damage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: p53-Independent DNA Damage Response

Phosphorylation of Cdc25A at Ser-123 by Chk2
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitination of phosphorylated Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
directly activates: Proteolytic degradation of ubiquitinated-Cdc25A
directly activates: Catalysis812

Proteolytic degradation of ubiquitinated-Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Phosphorylation and activation of Chk1 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
directly activates: Phosphorylation of Cdc25A at Ser-123 by Chk1
directly activates: BiochemicalReaction1852
directly activates: BiochemicalReaction1861
directly activates: Catalysis814
directly activates: Catalysis818
directly activates: Catalysis822

Phosphorylation of Cdc25A at Ser-123 by Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

p53-Independent DNA Damage Response
type: GO_0008150

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
type: GO_0008150
BFO_0000050: p53-Independent DNA Damage Response