CHEK1
CHK1
UniProt:O14757 CHEK1
CDS1
CHEK2
CHK2
RAD53
UniProt:O96017-12 CHEK2
ATM
UniProt:Q13315 ATM
Phosphorylation of Cdc25A at Ser-123 in response to DNA damage
Phosphorylation of Cdc25A at Ser-123 by Chk2
Ubiquitination of phosphorylated Cdc25A
Proteolytic degradation of ubiquitinated-Cdc25A
Phosphorylation and activation of Chk1 by ATM
Phosphorylation of Cdc25A at Ser-123 by Chk1
p53-Independent DNA Damage Response
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A