UniProt:Q8IVQ6 ZDHHC21
label: ZDHHC21

N-myristoylation of eNOS
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: palmitoylation of eNOS
directly activates: Catalysis2584

palmitoylation of eNOS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: UniProt:Q8IVQ6 ZDHHC21
type: GO_0016409
BFO_0000050: eNOS activation
directly activates: eNOS translocation from Golgi to Caveolae

eNOS translocation from Golgi to Caveolae
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: eNOS associates with Caveolin-1
directly activates: depalmitoylation of eNOS
directly activates: Catalysis2587

eNOS associates with Caveolin-1
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: eNOS:Caveolin-1 complex binds to CaM
directly activates: BiochemicalReaction5381

eNOS:Caveolin-1 complex binds to CaM
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: HSP90 binds eNOS:Caveolin-1:CaM complex

HSP90 binds eNOS:Caveolin-1:CaM complex
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex

Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: AKT1 binds eNOS complex via HSP90

AKT1 binds eNOS complex via HSP90
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: AKT1 phosphorylates eNOS

AKT1 phosphorylates eNOS
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: NO biosynthesis
directly activates: Catalysis2585

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: NO biosynthesis
directly activates: Catalysis2585

NO biosynthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004517
BFO_0000050: eNOS activation

Uncoupled eNOS favours the formation of superoxide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016175
BFO_0000050: eNOS activation
directly activates: Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)

Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: BiochemicalReaction5391

depalmitoylation of eNOS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008474
BFO_0000050: eNOS activation
directly activates: depalmitoylated eNOS translocates from plasma membrane

depalmitoylated eNOS translocates from plasma membrane
type: GO_0003674
BFO_0000050: eNOS activation
directly activates: palmitoylation of eNOS
directly activates: AKT1 binds eNOS complex via HSP90
directly activates: Catalysis2584

eNOS activation
type: GO_0008150