UniProt:Q8IVQ6 ZDHHC21
ZDHHC21
N-myristoylation of eNOS
palmitoylation of eNOS
eNOS translocation from Golgi to Caveolae
eNOS associates with Caveolin-1
eNOS:Caveolin-1 complex binds to CaM
HSP90 binds eNOS:Caveolin-1:CaM complex
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
AKT1 binds eNOS complex via HSP90
AKT1 phosphorylates eNOS
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
NO biosynthesis
Uncoupled eNOS favours the formation of superoxide
Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
depalmitoylation of eNOS
depalmitoylated eNOS translocates from plasma membrane
eNOS activation