KMO
UniProt:O15229 KMO
AFMID
UniProt:Q63HM1 AFMID
kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1]
tryptophan + O2 => N-formylkynurenine [TDO]
tryptophan + O2 => N-formylkynurenine [IDO]
tryptophan + O2 => N-formylkynurenine [IDO2]
N-formylkynurenine + H2O => kynurenine + formate
kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [mitochondrial]
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial]
Tryptophan catabolism