KMO
label: UniProt:O15229 KMO

AFMID
label: UniProt:Q63HM1 AFMID

kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016212
BFO_0000050: Tryptophan catabolism
directly activates: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]

tryptophan + O2 => N-formylkynurenine [TDO]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004833
BFO_0000050: Tryptophan catabolism
directly activates: N-formylkynurenine + H2O => kynurenine + formate
directly activates: Catalysis2883

tryptophan + O2 => N-formylkynurenine [IDO]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004833
BFO_0000050: Tryptophan catabolism
directly activates: N-formylkynurenine + H2O => kynurenine + formate
directly activates: Catalysis2883

tryptophan + O2 => N-formylkynurenine [IDO2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004833
BFO_0000050: Tryptophan catabolism

N-formylkynurenine + H2O => kynurenine + formate
type: Restriction
  on property: enabled by
  some values from: AFMID
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004061
BFO_0000050: Tryptophan catabolism
directly activates: kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1]
directly activates: kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
directly activates: kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
directly activates: Catalysis1292
directly activates: Catalysis2884
directly activates: Catalysis2885
directly activates: Control222

kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016212
BFO_0000050: Tryptophan catabolism
directly activates: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]

4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]
type: GO_0003674
BFO_0000050: Tryptophan catabolism
label: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic]

kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
type: Restriction
  on property: enabled by
  some values from: KMO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004502
BFO_0000050: Tryptophan catabolism
directly activates: 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
directly activates: Catalysis2886

3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030429
BFO_0000050: Tryptophan catabolism
directly activates: 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
directly activates: Catalysis2887

3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000334
BFO_0000050: Tryptophan catabolism
directly activates: BiochemicalReaction5624
directly activates: 2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2
directly activates: Catalysis2888

2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016831
BFO_0000050: Tryptophan catabolism
directly activates: 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
directly activates: Catalysis2889

2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047102
BFO_0000050: Tryptophan catabolism

kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016212
BFO_0000050: Tryptophan catabolism
directly activates: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [mitochondrial]

4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [mitochondrial]
type: GO_0003674
BFO_0000050: Tryptophan catabolism
label: 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial]

Tryptophan catabolism
type: GO_0008150