Recruitment of TRAF3 to IPS-1
TBK1/IKK epsilon complex interacts with IPS-1 bound TRAF3
Recruitment of IRF3/7Â
Phosphorylation and release of IRF3/IRF7
Dimerization of Phospho IRF3 or phospho IRF7
Translocation of phosphorylated IRF3/7 dimers into nucleus
Interaction of CBP/p300 with p-IRF3 dimer
IRF3:CBP/p300 complex binds the promoters of IFN-beta
TRAF3-dependent IRF activation pathway
Expression of IFN-beta