DICER
label: DICER1
label: HERNA
label: KIAA0928
label: UniProt:Q9UPY3 DICER1

Dicer cleaves double-stranded RNA to yield double-stranded siRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DICER
type: GO_0004525
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Duplex siRNA is loaded into Argonaute
directly activates: BiochemicalReaction555

Duplex siRNA is loaded into Argonaute
type: GO_0003674
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Cleavage-based removal of the siRNA passenger strand by AGO2
directly activates: Removal of siRNA passenger strand
directly activates: Catalysis202

Cleavage-based removal of the siRNA passenger strand by AGO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: BiochemicalReaction553
directly activates: BiochemicalReaction554
directly activates: Catalysis203

Removal of siRNA passenger strand
type: GO_0003674
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis

Small Interfering RNA (siRNA) Biogenesis
type: GO_0008150