NOTCH2-ligand complex is cleaved to produce NEXT2
NEXT2 is cleaved to produce NICD2
NICD2 traffics to the nucleus
DLL1 binds NOTCH2
JAG1 binds NOTCH2
JAG2 binds NOTCH2
DLL4 binds NOTCH2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
NOTCH2 binds CNTN1
Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
NOTCH2 binds MDK
NICD2 binds RBPJ and MAML in the nucleus
NOTCH2 coactivator complex binds HES1 promoter
NOTCH2 stimulates HES1 transcription
NOTCH2 coactivator complex binds HES5 promoter
NOTCH2 stimulates transcription of HES5
NOTCH2 coactivator complex binds FCER2 promoter
NOTCH2 stimulates transcription of FCER2 (CD23A)
NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter
NOTCH2 stimulates GZMB transcription
Signaling by NOTCH2
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 intracellular domain regulates transcription