NOTCH2-ligand complex is cleaved to produce NEXT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NEXT2 is cleaved to produce NICD2
directly activates: Catalysis1437

NEXT2 is cleaved to produce NICD2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NICD2 traffics to the nucleus

NICD2 traffics to the nucleus
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NICD2 binds RBPJ and MAML in the nucleus

DLL1 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

JAG1 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

JAG2 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

DLL4 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NOTCH2-ligand complex is cleaved to produce NEXT2
directly activates: Catalysis558

NOTCH2 binds CNTN1
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
directly activates: Control334

Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 binds MDK
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus

NICD2 binds RBPJ and MAML in the nucleus
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 coactivator complex binds HES1 promoter
directly activates: NOTCH2 coactivator complex binds HES5 promoter
directly activates: NOTCH2 coactivator complex binds FCER2 promoter
directly activates: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter

NOTCH2 coactivator complex binds HES1 promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates HES1 transcription
directly activates: Control335

NOTCH2 stimulates HES1 transcription
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

NOTCH2 coactivator complex binds HES5 promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates transcription of HES5
directly activates: Control336

NOTCH2 stimulates transcription of HES5
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

NOTCH2 coactivator complex binds FCER2 promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates transcription of FCER2 (CD23A)
directly activates: Control337

NOTCH2 stimulates transcription of FCER2 (CD23A)
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates GZMB transcription
directly activates: Control338

NOTCH2 stimulates GZMB transcription
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

Signaling by NOTCH2
type: GO_0008150

NOTCH2 Activation and Transmission of Signal to the Nucleus
type: GO_0008150
BFO_0000050: Signaling by NOTCH2

NOTCH2 intracellular domain regulates transcription
type: GO_0008150
BFO_0000050: Signaling by NOTCH2