FUR
label: FURIN
label: PACE
label: PCSK3
label: UniProt:P09958 FURIN

C3orf9
label: CLP46
label: KTELC1
label: MDS010
label: MDSRP
label: POGLUT1
label: UNQ490/PRO1006
label: UniProt:Q8NBL1 POGLUT1

FUT12
label: KIAA0180
label: POFUT1
label: UniProt:Q9H488 POFUT1

Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: NEXT1 is cleaved to produce NICD1
directly activates: Catalysis1422

NOTCH2-ligand complex is cleaved to produce NEXT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NEXT2 is cleaved to produce NICD2
directly activates: Catalysis1437

Notch 3-ligand complex is cleaved to produce NEXT3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Signaling by NOTCH3
directly activates: NEXT3 is cleaved to produce NICD3
directly activates: Catalysis1438

Notch 4-ligand complex is cleaved to produce NEXT4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Signaling by NOTCH4
directly activates: NEXT4 is cleaved to produce NICD4
directly activates: Catalysis1439

NOTCH1 binds DLL1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

NOTCH1 binds DLL4
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

NOTCH1 binds JAG1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

NOTCH1 binds JAG2
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
directly activates: Catalysis557

NEXT1 is cleaved to produce NICD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: NICD1 traffics to nucleus

NICD1 traffics to nucleus
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: NICD1 displaces co-repressor complex from RBPJ (CSL)
directly activates: NICD1 binds HIF1A
directly activates: TemplateReaction162
directly activates: TemplateReactionRegulation189
directly activates: TemplateReactionRegulation190

DTX binds NOTCH1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Contactin-1 (CNTN1) binds NOTCH1
directly activates: NOTCH1 binds DNER
directly activates: DTX recruits beta-arrestin (ARRB) to NOTCH

Contactin-1 (CNTN1) binds NOTCH1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Cleavage of CNTN1:NOTCH1 complex releases NICD1
directly activates: Control254

Cleavage of CNTN1:NOTCH1 complex releases NICD1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 binds DNER
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Cleavage of DNER:NOTCH1 complex releases NICD1
directly activates: Control255

Cleavage of DNER:NOTCH1 complex releases NICD1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

DTX recruits beta-arrestin (ARRB) to NOTCH
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: ARRB mediates NOTCH1 ubiquitination
directly activates: Catalysis1423

ARRB mediates NOTCH1 ubiquitination
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

ITCH binds DTX
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: ITCH ubiquitinates DTX
directly activates: Catalysis1424

ITCH ubiquitinates DTX
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 binds DLL/JAG ligand in cis
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 binds DLK1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 associates with negative regulators NUMB and ITCH
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of NOTCH1 by ITCH in the absence of ligand
directly activates: Catalysis1425

Ubiquitination of NOTCH1 by ITCH in the absence of ligand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NICD1 displaces co-repressor complex from RBPJ (CSL)
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: NICD1 in complex with RBPJ (CSL) recruits MAML

NICD1 in complex with RBPJ (CSL) recruits MAML
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: MAML in complex with NICD1 recruits CDK8
directly activates: NOTCH1 stimulates HES1 transcription
directly activates: NOTCH1 stimulates MYC transcription
directly activates: NOTCH1 stimulates HES5 transcription
directly activates: NOTCH1 stimulates HEY transcription
directly activates: TemplateReactionRegulation51
directly activates: TemplateReactionRegulation52
directly activates: TemplateReactionRegulation53
directly activates: TemplateReactionRegulation54

HES1 binds TLE
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

MAML in complex with NICD1 recruits CDK8
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: NICD1 is phosphorylated by CDK8
directly activates: Catalysis1426

NICD1 is phosphorylated by CDK8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: Phosphorylated NICD1 binds FBXW7

Phosphorylated NICD1 binds FBXW7
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: Ubiquitination of NICD1 by FBWX7
directly activates: Catalysis1427

Ubiquitination of NICD1 by FBWX7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NICD1 binds HIF1A
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NEXT2 is cleaved to produce NICD2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NICD2 traffics to the nucleus

NEXT3 is cleaved to produce NICD3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: Signaling by NOTCH3
directly activates: NICD3 traffics to the nucleus

NEXT4 is cleaved to produce NICD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: Signaling by NOTCH4
directly activates: NICD4 traffics to the nucleus

NICD2 traffics to the nucleus
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NICD2 binds RBPJ and MAML in the nucleus

NICD3 traffics to the nucleus
type: GO_0003674
BFO_0000050: Signaling by NOTCH3

NICD4 traffics to the nucleus
type: GO_0003674
BFO_0000050: Signaling by NOTCH4

NOTCH1 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
directly activates: MIR200B/C microRNAs bind NOTCH1 mRNA
directly activates: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
directly activates: NOTCH1 mRNA translation controlled by miRNAs
directly activates: Control321
directly activates: Control322
directly activates: Control323

NOTCH2 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
directly activates: NOTCH2 mRNA translation controlled by miRNAs
directly activates: Control324

NOTCH3 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
directly activates: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
directly activates: NOTCH3 mRNA translation controlled by miRNAs
directly activates: Control325
directly activates: Control326

NOTCH4 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
directly activates: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
directly activates: NOTCH4 mRNA translation controlled by miRNAs
directly activates: Control327
directly activates: Control328

p53 positively regulates transcription of MIR34 microRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA

MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR200B/C microRNAs bind NOTCH1 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

NOTCH1 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

NOTCH2 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

NOTCH3 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

NOTCH4 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

Fucosylation of Pre-NOTCH by POFUT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FUT12
type: Restriction
  on property: enabled by
  some values from: FUT12
type: Restriction
  on property: enabled by
  some values from: FUT12
type: Restriction
  on property: enabled by
  some values from: FUT12
type: GO_0046922
BFO_0000050: Pre-NOTCH Processing in the Endoplasmic Reticulum
directly activates: Glucosylation of Pre-NOTCH by POGLUT1
directly activates: Catalysis1870

Glucosylation of Pre-NOTCH by POGLUT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: enabled by
  some values from: C3orf9
type: Restriction
  on property: enabled by
  some values from: C3orf9
type: Restriction
  on property: enabled by
  some values from: C3orf9
type: Restriction
  on property: enabled by
  some values from: C3orf9
type: GO_0035251
BFO_0000050: Pre-NOTCH Processing in the Endoplasmic Reticulum
directly activates: Transport of NOTCH precursor to Golgi
directly activates: Control329
directly activates: Control330
directly activates: Control331

Transport of NOTCH precursor to Golgi
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: NOTCH precursor cleaved to form mature NOTCH
directly activates: Glycosylation of Pre-NOTCH by FRINGE
directly activates: Catalysis1871
directly activates: Catalysis1872

NOTCH precursor cleaved to form mature NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Mature NOTCH heterodimer traffics to the plasma membrane
directly activates: Control332

Glycosylation of Pre-NOTCH by FRINGE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0033829
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Galactosylation of Pre-NOTCH
directly activates: Catalysis1873

Galactosylation of Pre-NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Sialylation of Pre-NOTCH
directly activates: Catalysis1874

Sialylation of Pre-NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Fringe-modified Pre-NOTCH is cleaved by FURIN
directly activates: Catalysis1875

Fringe-modified Pre-NOTCH is cleaved by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Transport of fringe-modified NOTCH to plasma membrane
directly activates: Control333

Mature NOTCH heterodimer traffics to the plasma membrane
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: NOTCH1 binds DLL1
directly activates: NOTCH1 binds DLL4
directly activates: NOTCH1 binds JAG1
directly activates: NOTCH1 binds JAG2
directly activates: DTX binds NOTCH1
directly activates: NOTCH1 binds DLL/JAG ligand in cis
directly activates: NOTCH1 binds DLK1
directly activates: NOTCH1 associates with negative regulators NUMB and ITCH
directly activates: DLL1 binds NOTCH2
directly activates: JAG1 binds NOTCH2
directly activates: JAG2 binds NOTCH2
directly activates: DLL4 binds NOTCH2
directly activates: NOTCH2 binds CNTN1
directly activates: NOTCH2 binds MDK

Transport of fringe-modified NOTCH to plasma membrane
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: NOTCH1 binds DLL1
directly activates: NOTCH1 binds DLL4
directly activates: NOTCH1 associates with negative regulators NUMB and ITCH
directly activates: DLL1 binds NOTCH2
directly activates: JAG1 binds NOTCH2

DLL1 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

JAG1 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

JAG2 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

DLL4 binds NOTCH2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
directly activates: Catalysis1876

Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: NOTCH2-ligand complex is cleaved to produce NEXT2
directly activates: Catalysis558

NOTCH2 binds CNTN1
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus
directly activates: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
directly activates: Control334

Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 binds MDK
type: GO_0003674
BFO_0000050: NOTCH2 Activation and Transmission of Signal to the Nucleus

NICD2 binds RBPJ and MAML in the nucleus
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 coactivator complex binds HES1 promoter
directly activates: NOTCH2 coactivator complex binds HES5 promoter
directly activates: NOTCH2 coactivator complex binds FCER2 promoter
directly activates: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter

NOTCH2 coactivator complex binds HES1 promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates HES1 transcription
directly activates: Control335

NOTCH2 stimulates HES1 transcription
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

NOTCH2 coactivator complex binds HES5 promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates transcription of HES5
directly activates: Control336

NOTCH2 stimulates transcription of HES5
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

NOTCH2 coactivator complex binds FCER2 promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates transcription of FCER2 (CD23A)
directly activates: Control337

NOTCH2 stimulates transcription of FCER2 (CD23A)
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription
directly activates: NOTCH2 stimulates GZMB transcription
directly activates: Control338

NOTCH2 stimulates GZMB transcription
type: GO_0003674
BFO_0000050: NOTCH2 intracellular domain regulates transcription

Notch 3 heterodimer binds with a Notch ligand in the extracellular space
type: GO_0003674
BFO_0000050: Signaling by NOTCH3
directly activates: Notch 3-ligand complex is cleaved to produce NEXT3
directly activates: Catalysis559

Notch 4 heterodimer binds with a Notch ligand in the extracellular space
type: GO_0003674
BFO_0000050: Signaling by NOTCH4
directly activates: Notch 4-ligand complex is cleaved to produce NEXT4
directly activates: Catalysis560

NOTCH Signaling Pathway
type: GO_0008150
label: Signaling by NOTCH

Pre-NOTCH Expression and Processing
type: GO_0008150
BFO_0000050: NOTCH Signaling Pathway

Pre-NOTCH Transcription and Translation
type: GO_0008150
BFO_0000050: Pre-NOTCH Expression and Processing

Pre-NOTCH Processing in the Endoplasmic Reticulum
type: GO_0008150
BFO_0000050: Pre-NOTCH Expression and Processing

Pre-NOTCH Processing in Golgi
type: GO_0008150
BFO_0000050: Pre-NOTCH Expression and Processing

Signaling by NOTCH2
type: GO_0008150
BFO_0000050: NOTCH Signaling Pathway

NOTCH2 Activation and Transmission of Signal to the Nucleus
type: GO_0008150
BFO_0000050: Signaling by NOTCH2

NOTCH2 intracellular domain regulates transcription
type: GO_0008150
BFO_0000050: Signaling by NOTCH2

Signaling by NOTCH3
type: GO_0008150
BFO_0000050: NOTCH Signaling Pathway

Signaling by NOTCH4
type: GO_0008150
BFO_0000050: NOTCH Signaling Pathway

Signaling by NOTCH1
type: GO_0008150
BFO_0000050: NOTCH Signaling Pathway

Activated NOTCH1 Transmits Signal to the Nucleus
type: GO_0008150
BFO_0000050: Signaling by NOTCH1

NOTCH1 Intracellular Domain Regulates Transcription
type: GO_0008150
BFO_0000050: Signaling by NOTCH1

NOTCH1 stimulates HES1 transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: HES1 binds TLE

NOTCH1 stimulates MYC transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: TemplateReaction33
directly activates: TemplateReactionRegulation49

NOTCH1 stimulates HES5 transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NOTCH1 stimulates HEY transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription