FUR
FURIN
PACE
PCSK3
UniProt:P09958 FURIN
C3orf9
CLP46
KTELC1
MDS010
MDSRP
POGLUT1
UniProt:Q8NBL1 POGLUT1
FUT12
KIAA0180
POFUT1
UniProt:Q9H488 POFUT1
Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
NOTCH2-ligand complex is cleaved to produce NEXT2
Notch 3-ligand complex is cleaved to produce NEXT3
Notch 4-ligand complex is cleaved to produce NEXT4
NOTCH1 binds DLL1
NOTCH1 binds DLL4
NOTCH1 binds JAG1
NOTCH1 binds JAG2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
NEXT1 is cleaved to produce NICD1
NICD1 traffics to nucleus
DTX binds NOTCH1
Contactin-1 (CNTN1) binds NOTCH1
Cleavage of CNTN1:NOTCH1 complex releases NICD1
NOTCH1 binds DNER
Cleavage of DNER:NOTCH1 complex releases NICD1
DTX recruits beta-arrestin (ARRB) to NOTCH
ARRB mediates NOTCH1 ubiquitination
ITCH binds DTX
ITCH ubiquitinates DTX
NOTCH1 binds DLL/JAG ligand in cis
NOTCH1 binds DLK1
NOTCH1 associates with negative regulators NUMB and ITCH
Ubiquitination of NOTCH1 by ITCH in the absence of ligand
NICD1 displaces co-repressor complex from RBPJ (CSL)
NICD1 in complex with RBPJ (CSL) recruits MAML
HES1 binds TLE
MAML in complex with NICD1 recruits CDK8
NICD1 is phosphorylated by CDK8
Phosphorylated NICD1 binds FBXW7
Ubiquitination of NICD1 by FBWX7
NICD1 binds HIF1A
NEXT2 is cleaved to produce NICD2
NEXT3 is cleaved to produce NICD3
NEXT4 is cleaved to produce NICD4
NICD2 traffics to the nucleus
NICD3 traffics to the nucleus
NICD4 traffics to the nucleus
NOTCH1 gene transcription
NOTCH2 gene transcription
NOTCH3 gene transcription
NOTCH4 gene transcription
p53 positively regulates transcription of MIR34 microRNAs
MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
MIR200B/C microRNAs bind NOTCH1 mRNA
MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
NOTCH1 mRNA translation controlled by miRNAs
NOTCH2 mRNA translation controlled by miRNAs
NOTCH3 mRNA translation controlled by miRNAs
NOTCH4 mRNA translation controlled by miRNAs
Fucosylation of Pre-NOTCH by POFUT1
Glucosylation of Pre-NOTCH by POGLUT1
Transport of NOTCH precursor to Golgi
NOTCH precursor cleaved to form mature NOTCH
Glycosylation of Pre-NOTCH by FRINGE
Galactosylation of Pre-NOTCH
Sialylation of Pre-NOTCH
Fringe-modified Pre-NOTCH is cleaved by FURIN
Mature NOTCH heterodimer traffics to the plasma membrane
Transport of fringe-modified NOTCH to plasma membrane
DLL1 binds NOTCH2
JAG1 binds NOTCH2
JAG2 binds NOTCH2
DLL4 binds NOTCH2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
NOTCH2 binds CNTN1
Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
NOTCH2 binds MDK
NICD2 binds RBPJ and MAML in the nucleus
NOTCH2 coactivator complex binds HES1 promoter
NOTCH2 stimulates HES1 transcription
NOTCH2 coactivator complex binds HES5 promoter
NOTCH2 stimulates transcription of HES5
NOTCH2 coactivator complex binds FCER2 promoter
NOTCH2 stimulates transcription of FCER2 (CD23A)
NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter
NOTCH2 stimulates GZMB transcription
Notch 3 heterodimer binds with a Notch ligand in the extracellular space
Notch 4 heterodimer binds with a Notch ligand in the extracellular space
NOTCH Signaling Pathway
Signaling by NOTCH
Pre-NOTCH Expression and Processing
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Processing in Golgi
Signaling by NOTCH2
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 intracellular domain regulates transcription
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Activated NOTCH1 Transmits Signal to the Nucleus
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 stimulates HES1 transcription
NOTCH1 stimulates MYC transcription
NOTCH1 stimulates HES5 transcription
NOTCH1 stimulates HEY transcription