CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
PLC1
PLCG1
UniProt:P19174 PLCG1
CUL5
UniProt:Q93034 CUL5
VACM1
FLRF
NRDP1
RNF41
SBBI03
UniProt:Q9H4P4 RNF41
CHIP
PP1131
STUB1
UniProt:Q9UNE7 STUB1
Active PLCG1 hydrolyses PIP2
DAG stimulates protein kinase C-delta
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Adenylate cyclase produces cAMP
cAMP induces dissociation of inactive PKA tetramers
PKA catalytic subunit translocates to the nucleus
PKA phosphorylates CREB
Dimerisation of CREB
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
CaMK IV phosphorylates CREB
Calmodulin activates Cam-PDE 1
cAMP hydrolysis by Cam-PDE 1
Inhibition of GRK2 by calmodulin
PKC phosphorylates GRK2
Calcium binds calmodulin
ERBB3 binds neuregulins
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
SRC family kinases phosphorylate ERBB2
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
Trans-autophosphorylation of ERBB2 heterodimers
SHC1 binds phosphorylated ERBB2 heterodimers
SHC1 phosphorylation by ERBB2 heterodimers
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
Binding of PI3K subunit p85 (PIK3R1) to ERBB2:P-ERBB3 heterodimer
Recruitment of PI3K subunit p110 (PIK3CA) by PIK3R1 bound to phosphorylated heterodimer of ERBB2 and ERBB3.
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB2:p-ERBB4 CYT-1 heterodimers
Recruitment of PI3K subunit p110 (PIK3CA) by PIK3R1bound to ERBB2:ERBB4cyt1 heterodimer.
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
Binding of PI3K subunit p85 (PIK3R1) to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
Recruitment of catalytic PI3K subunit p110 (PIK3CA) by PIK3R1 bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
PLCG1 binds to p-ERBB2:p-EGFR
Phospholipase C gamma 1 (PLCG1) binds to phosphorylated ERBB2:EGFR heterodimer
PLCG1 phosphorylation by p-EGFR:p-ERBB2
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
ERBB3 binds RNF41 ubiquitin ligase
RNF41 ubiquitinates ERBB3
Self-ubiquitination of RNF41
Phosphorylation of USP8 by P-AKT
Ubiquitinated RNF41 binds P-USP8
Deubiquitination of RNF41 by P-USP8
RNF41 binds neuregulin-activated ERBB3
RNF41 ubiquitinates activated ERBB3
CHIP (STUB1) mediates ubiquitination of ERBB2
CUL5 mediates ubiquitination of ERBB2
MATK (CSK homologous kinase) binds phosphorylated ERBB2
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
Signaling by ERBB2
SHC1 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
DAG and IP3 signaling
CaM pathway
Calmodulin induced events
PKA-mediated phosphorylation of CREB
PKA activation
CaMK IV-mediated phosphorylation of CREB
Cam-PDE 1 activation