The ligand trap binds the ligand BMP2, blocking BMP signalling
type: GO_0003674
BFO_0000050: Signaling by BMP

Formation of a heteromeric BMP receptor complex
type: GO_0003674
BFO_0000050: Signaling by BMP
directly activates: BMP2 binds to the receptor complex
directly activates: Catalysis1850

BMP2 binds to the receptor complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0005160
BFO_0000050: Signaling by BMP
directly activates: Type II receptor phosphorylates type I receptor
directly activates: Catalysis1851

Type II receptor phosphorylates type I receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016362
BFO_0000050: Signaling by BMP
directly activates: An anchoring protein, Endofin, recruits R-Smad1/5/8
directly activates: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

An anchoring protein, Endofin, recruits R-Smad1/5/8
type: GO_0003674
BFO_0000050: Signaling by BMP
directly activates: Activated type I receptor phosphorylates R-Smad1/5/8 directly
directly activates: Catalysis1853

I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated
type: GO_0003674
BFO_0000050: Signaling by BMP

Activated type I receptor phosphorylates R-Smad1/5/8 directly
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004675
BFO_0000050: Signaling by BMP
directly activates: Phospho-R-Smad1/5/8 dissociates from the receptor complex

Phospho-R-Smad1/5/8 dissociates from the receptor complex
type: GO_0003674
BFO_0000050: Signaling by BMP
directly activates: I-Smad competes with Co-Smad for R-Smad1/5/8
directly activates: Phospho-R-Smad1/5/8 forms a complex with Co-Smad

I-Smad competes with Co-Smad for R-Smad1/5/8
type: GO_0003674
BFO_0000050: Signaling by BMP

Phospho-R-Smad1/5/8 forms a complex with Co-Smad
type: GO_0003674
BFO_0000050: Signaling by BMP
directly activates: The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus
type: GO_0003674
BFO_0000050: Signaling by BMP
directly activates: Catalysis1854
directly activates: Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

SKI complexes with the Smad complex, suppressing BMP2 signalling
type: GO_0003674
BFO_0000050: Signaling by BMP

I-Smad competes with R-Smad1/5/8 for type I receptor
type: GO_0003674
BFO_0000050: Signaling by BMP

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Signaling by BMP

Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Signaling by BMP

Signaling by BMP
type: GO_0008150