CSBP
label: CSBP1
label: CSBP2
label: CSPB1
label: MAPK14
label: MXI2
label: SAPK2A
label: UniProt:Q16539 MAPK14

Phosphorylation of cPLA2 by MAPK p38 alpha
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: enabled by
  some values from: CSBP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: BiochemicalReaction4402

ADP binds to P2Y purinoceptor 12
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Activated P2Y purinoceptor 12 binds G-protein Gi

Activated P2Y purinoceptor 12 binds G-protein Gi
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Gi activation by P2Y purinoceptor 12
directly activates: Catalysis1010

Gi activation by P2Y purinoceptor 12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: Dissociation of the P2Y purinoceptor 12:Gi complex

Dissociation of the P2Y purinoceptor 12:Gi complex
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 12
directly activates: BiochemicalReaction3760
directly activates: BiochemicalReaction4352
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1883
directly activates: Control343

ADP binds to P2Y purinoceptor 1
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Activated P2Y purinoceptor 1 binds G-protein Gq

Activated P2Y purinoceptor 1 binds G-protein Gq
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Gq activation by P2Y purinoceptor 1
directly activates: Catalysis1011

Gq activation by P2Y purinoceptor 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Dissociation of the P2Y purinoceptor 1:Gq complex

Dissociation of the P2Y purinoceptor 1:Gq complex
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Src activation following P2Y purinoceptor activation
directly activates: P2Y purinoceptor 1 activates MAP kinase p38 alpha
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386
directly activates: Catalysis1012
directly activates: Catalysis1889
directly activates: Control345

Src activation following P2Y purinoceptor activation
type: GO_0003674
BFO_0000050: ADP signalling through P2Y purinoceptor 1

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: ADP signalling through P2Y purinoceptor 1
directly activates: Phosphorylation of cPLA2 by MAPK p38 alpha
directly activates: Catalysis1009

TP receptor can bind thromboxane
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Activated TP receptor binds G-proten Gq
directly activates: Activated TP receptor binds G-protein G13
directly activates: BiochemicalReaction4372

Activated TP receptor binds G-proten Gq
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Gq activation by TP receptor
directly activates: Catalysis1013

Activated TP receptor binds G-protein G13
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: G13 activation by TP receptor
directly activates: Catalysis1014

Gq activation by TP receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Dissociation of the TP:Gq complex

G13 activation by TP receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: Dissociation of the TP:G13 complex

Dissociation of the TP:Gq complex
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: BiochemicalReaction4364
directly activates: BiochemicalReaction4365
directly activates: BiochemicalReaction4366
directly activates: BiochemicalReaction4367
directly activates: BiochemicalReaction4368
directly activates: BiochemicalReaction4370
directly activates: Catalysis1889
directly activates: Control345

Dissociation of the TP:G13 complex
type: GO_0003674
BFO_0000050: Thromboxane signalling through TP receptor
directly activates: BiochemicalReaction4375
directly activates: BiochemicalReaction4380
directly activates: BiochemicalReaction4382
directly activates: Catalysis1893

Signal amplification
type: GO_0008150

ADP signalling through P2Y purinoceptor 12
type: GO_0008150
BFO_0000050: Signal amplification

ADP signalling through P2Y purinoceptor 1
type: GO_0008150
BFO_0000050: Signal amplification

Thromboxane signalling through TP receptor
type: GO_0008150
BFO_0000050: Signal amplification