unfolded actin/tubulin associates with prefoldin
Actin/tubulin:prefoldin complex associates with CCT/TriC
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC
Exchange of ADP for ATP in CCT/TriC:actin complex
Hydrolysis of ATP and release of folded actin from CCT/TriC
Association of CCT/TriC with sphingosine kinase 1
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A
Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D
Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A
alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E
alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi
Protein folding
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
Post-chaperonin tubulin folding pathway