SRC
label: SRC1
label: UniProt:P12931-1 SRC

PTP1B
label: PTPN1
label: UniProt:P18031 PTPN1

Translocation of RIAM to plasma membrane
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activation of Talin

Activation of Talin
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Integrin alphaIIb beta3 activation

Integrin alphaIIb beta3 activation
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Interaction of integrin alphaIIb beta3 with Fibrinogen
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Interaction of integrin alphaIIb beta3 with Fibrinogen
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Clustering of Integrin alphaIIb beta3 complexes

Clustering of Integrin alphaIIb beta3 complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Release of CSK from SRC

Release of CSK from SRC
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Dephosphorylation of inactive SRC by PTPB1
directly activates: Catalysis1029

Dephosphorylation of inactive SRC by PTPB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of SRC
directly activates: Catalysis1030

Autophosphorylation of SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of FADK1 to Focal complexes
directly activates: SYK binds to integrin alphaIIb beta3

Translocation of FADK1 to Focal complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of FADK1 at Y397
directly activates: Catalysis1031

Autophosphorylation of FADK1 at Y397
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Phosphorylation of pFADK1 by SRC
directly activates: Catalysis1032

Phosphorylation of pFADK1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Recruitment of GRB2 to p-FADK1
directly activates: Recruitment of p130Cas to FADK1

Recruitment of GRB2 to p-FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins
directly activates: Interaction of SOS with GRB2 bound to FADK1

Interaction of SOS with GRB2 bound to FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins

Recruitment of p130Cas to FADK1
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Phosphorylation of p130Cas by SRC-FADK1 complex
directly activates: Catalysis1033

Phosphorylation of p130Cas by SRC-FADK1 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Crk binding to p130cas

Crk binding to p130cas
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Activated integrin alphaIIb beta3 binds SHC1
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 dissociates from integrin alphaIIb beta3

SHC1 dissociates from integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: BiochemicalReaction3816

SYK binds to integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SYK activation by SRC
directly activates: Catalysis1035

SYK activation by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling

Alpha-2 adrenoceptors bind catecholamines
type: GO_0003674
BFO_0000050: Adrenaline signalling through Alpha-2 adrenergic receptor
directly activates: BiochemicalReaction4354

Thrombin binding to GP1b:IX:V
type: GO_0003674
BFO_0000050: Platelet Aggregation (Plug Formation)

Thrombopoietin binds the thrombopoietin receptor
type: GO_0003674
BFO_0000050: Platelet Aggregation (Plug Formation)

Activation of Rap1 by membrane-associated GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Activation of Rap1 by cytosolic GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Platelet Aggregation (Plug Formation)
type: GO_0008150

Integrin alphaIIb beta3 signaling
type: GO_0008150
BFO_0000050: Platelet Aggregation (Plug Formation)

GRB2:SOS provides linkage to MAPK signaling for Intergrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

p130Cas linkage to MAPK signaling for integrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

Adrenaline signalling through Alpha-2 adrenergic receptor
type: GO_0008150
BFO_0000050: Platelet Aggregation (Plug Formation)