Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
GRB2:GAB1:PI3Kreg binds directly to p-FRS2:activated FGFR
GRB2:GAB1:PI3Kreg binds to p-SHP2 on p-FRS2:activated FGFR
PI3K catalytic subunit is recruited by FGFR-associated PI3KR1
PI3K catalytic subunit binds to GRB2:GAB1:PI3Kreg (indirect)
FGFR-associated PI3K phosphorylates PIP2 to PIP3
FGFR associated PI3K phosphorylates PIP2 to PIP3
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
PI-3K cascade