GCNT3
label: UniProt:O95395 GCNT3

SIAT1
label: ST6GAL1
label: UniProt:P15907 ST6GAL1

SIAT7B
label: SIATL1
label: ST6GALNAC2
label: STHM
label: UniProt:Q9UJ37 ST6GALNAC2

Addition of GalNAc to mucins to form the Tn antigen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004653
BFO_0000050: O-linked glycosylation of mucins
directly activates: C1GALT1 transfers galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
directly activates: Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
directly activates: Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein
directly activates: Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein
directly activates: Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
directly activates: Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein
directly activates: Catalysis1555
directly activates: Catalysis1557

C1GALT1 transfers galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0016263
BFO_0000050: O-linked glycosylation of mucins
directly activates: Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
directly activates: Catalysis1556

Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003829
BFO_0000050: O-linked glycosylation of mucins

Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008499
BFO_0000050: O-linked glycosylation of mucins
directly activates: Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein
directly activates: Catalysis1558

Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein
type: Restriction
  on property: enabled by
  some values from: GCNT3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003829
BFO_0000050: O-linked glycosylation of mucins

Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein
type: GO_0003674
BFO_0000050: O-linked glycosylation of mucins

Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein
type: GO_0003674
BFO_0000050: O-linked glycosylation of mucins
directly activates: Addition of galactose to Core 6 glycoprotein
directly activates: Catalysis1559

Addition of galactose to Core 6 glycoprotein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008378
BFO_0000050: O-linked glycosylation of mucins

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
type: GO_0003674
BFO_0000050: O-linked glycosylation of mucins

Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein
type: GO_0003674
BFO_0000050: O-linked glycosylation of mucins

Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: SIAT1
type: Restriction
  on property: enabled by
  some values from: SIAT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003835
BFO_0000050: Termination of O-glycan biosynthesis

Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: SIAT1
type: Restriction
  on property: enabled by
  some values from: SIAT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003835
BFO_0000050: Termination of O-glycan biosynthesis

GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: SIAT7B
type: Restriction
  on property: enabled by
  some values from: SIAT7B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008373
BFO_0000050: Termination of O-glycan biosynthesis

ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Termination of O-glycan biosynthesis
directly activates: ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen
directly activates: Catalysis1564

ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0047290
BFO_0000050: Termination of O-glycan biosynthesis

O-linked glycosylation of mucins
type: GO_0008150

Termination of O-glycan biosynthesis
type: GO_0008150
BFO_0000050: O-linked glycosylation of mucins