GCNT3
UniProt:O95395 GCNT3
SIAT1
ST6GAL1
UniProt:P15907 ST6GAL1
SIAT7B
SIATL1
ST6GALNAC2
STHM
UniProt:Q9UJ37 ST6GALNAC2
Addition of GalNAc to mucins to form the Tn antigen
C1GALT1 transfers galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein
Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein
Addition of galactose to Core 6 glycoprotein
Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein
Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position
GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position
ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position
ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis