LIG4
label: UniProt:P49917 LIG4

HYRC
label: HYRC1
label: PRKDC
label: UniProt:P78527 PRKDC

Association of Ku heterodimer with ends of DNA double-strand break
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks

Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Synapsis, or interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB

Autophosphorylation of DNA-PKcs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: HYRC
type: GO_0016301
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks

Synapsis, or interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Removal of 3'-phosphoglycolate (PG) moiety from DSB ends
directly activates: Removal of 3'-phosphate moiety from DSB ends
directly activates: Catalysis76
directly activates: Catalysis77
directly activates: Processing of DNA ends prior to end rejoining

Removal of 3'-phosphoglycolate (PG) moiety from DSB ends
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: Processing of DNA ends prior to end rejoining
directly activates: Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex

Removal of 3'-phosphate moiety from DSB ends
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: Processing of DNA ends prior to end rejoining
directly activates: Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex

Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Removal of repair proteins and ligation of the processed ends of the DNA double-strand break
directly activates: Catalysis78

Removal of repair proteins and ligation of the processed ends of the DNA double-strand break
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG4
type: GO_0003909
BFO_0000050: Nonhomologous End-joining (NHEJ)

Nonhomologous End-joining (NHEJ)
type: GO_0008150

Processing of DNA ends prior to end rejoining
type: GO_0008150
BFO_0000050: Nonhomologous End-joining (NHEJ)