CHAT
label: UniProt:P28329 CHAT

SLC6A12
label: UniProt:P48065 SLC6A12

ALDH5A1
label: SSADH
label: UniProt:P51649 ALDH5A1

SLC18A2
label: SVMT
label: UniProt:Q05940 SLC18A2
label: VMAT2

SLC18A3
label: UniProt:Q16572 SLC18A3
label: VACHT

ATA2
label: KIAA1382
label: SAT2
label: SLC38A2
label: SNAT2
label: UniProt:Q96QD8 SLC38A2

CHT1
label: SLC5A7
label: UniProt:Q9GZV3 SLC5A7

SLC32A1
label: UniProt:Q9H598 SLC32A1
label: VGAT
label: VIAAT

SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SLC6A12
type: Restriction
  on property: enabled by
  some values from: SLC6A12
type: Restriction
  on property: enabled by
  some values from: SLC6A12
type: Restriction
  on property: enabled by
  some values from: SLC6A12
type: GO_0015171
BFO_0000050: Reuptake of GABA

GAT1-3 mediate Na+/Cl- dependent GABA transport
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005332
BFO_0000050: Reuptake of GABA

Uptake of Noradrenaline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005326
BFO_0000050: Norepinephrine Neurotransmitter Release Cycle
directly activates: Metabolism of Noradrenaline
directly activates: Catalysis1639

Re-acidification of clathrin sculpted monoamine tranport vesicle lumen
type: GO_0003674
BFO_0000050: Norepinephrine Neurotransmitter Release Cycle
BFO_0000050: Serotonin Neurotransmitter Release Cycle
BFO_0000050: Dopamine Neurotransmitter Release Cycle
directly activates: Loading of dopamine into synaptic veiscles
directly activates: loading of Serotonin in synaptic vesicles
directly activates: Catalysis1636
directly activates: Catalysis1640

Loading of dopamine into synaptic veiscles
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: enabled by
  some values from: SLC18A2
type: Restriction
  on property: enabled by
  some values from: SLC18A2
type: Restriction
  on property: enabled by
  some values from: SLC18A2
type: Restriction
  on property: enabled by
  some values from: SLC18A2
type: GO_0008504
BFO_0000050: Norepinephrine Neurotransmitter Release Cycle
BFO_0000050: Dopamine Neurotransmitter Release Cycle
directly activates: Noradrenalin synaptic vesicle docking and priming
directly activates: Dopamine synaptic vesicle docking and priming
directly activates: BiochemicalReaction5779
directly activates: Catalysis1637
directly activates: Catalysis1649
directly activates: Catalysis2929

Noradrenalin synaptic vesicle docking and priming
type: Restriction
  on property: BFO_0000066
  some values from: GO_0045334
type: Restriction
  on property: BFO_0000066
  some values from: GO_0045334
type: GO_0000149
BFO_0000050: Norepinephrine Neurotransmitter Release Cycle
directly activates: Release of noradrenaline at the synapse
directly activates: Catalysis1638

Release of noradrenaline at the synapse
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: Norepinephrine Neurotransmitter Release Cycle
directly activates: Uptake of Noradrenaline
directly activates: Catalysis680

Metabolism of Noradrenaline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
type: GO_0042133
BFO_0000050: Norepinephrine Neurotransmitter Release Cycle

loading of Serotonin in synaptic vesicles
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: enabled by
  some values from: SLC18A2
type: Restriction
  on property: enabled by
  some values from: SLC18A2
type: GO_0008504
BFO_0000050: Serotonin Neurotransmitter Release Cycle
directly activates: Serotonin loaded synaptic vesicle docking and priming
directly activates: Catalysis1641

Serotonin loaded synaptic vesicle docking and priming
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: GO_0000149
BFO_0000050: Serotonin Neurotransmitter Release Cycle
directly activates: Release of docked serotonin loaded synaptic vesicle
directly activates: Catalysis1642

Release of docked serotonin loaded synaptic vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: Serotonin Neurotransmitter Release Cycle

L-Glutamine transport into neurons
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ATA2
type: Restriction
  on property: enabled by
  some values from: ATA2
type: GO_0015171
BFO_0000050: Glutamate Neurotransmitter Release Cycle
directly activates: Transport of L-Glutamine (cytosol) to mitochondrial matrix

Transport of L-Glutamine (cytosol) to mitochondrial matrix
type: GO_0003674
BFO_0000050: Glutamate Neurotransmitter Release Cycle
directly activates: glutamine + H2O => glutamate + NH4+ [GLS]
directly activates: Catalysis1644

glutamine + H2O => glutamate + NH4+ [GLS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004359
BFO_0000050: Glutamate Neurotransmitter Release Cycle
directly activates: Tranport of L-Glutamate (mitochondrial matrix) to cytosol
directly activates: L-Glutamate loading of synaptic vesicle
directly activates: Catalysis1645

Tranport of L-Glutamate (mitochondrial matrix) to cytosol
type: GO_0003674
BFO_0000050: Glutamate Neurotransmitter Release Cycle

L-Glutamate loading of synaptic vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005313
BFO_0000050: Glutamate Neurotransmitter Release Cycle
directly activates: Glutamate synaptic vesicle docking and priming
directly activates: Acetylcholine synaptic vesicle docking and priming
directly activates: Catalysis1646
directly activates: Catalysis1654
directly activates: Control298

Glutamate synaptic vesicle docking and priming
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000149
BFO_0000050: Glutamate Neurotransmitter Release Cycle
directly activates: release of L-Glutamate at the synapse
directly activates: Catalysis1647
directly activates: Control299

release of L-Glutamate at the synapse
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: Glutamate Neurotransmitter Release Cycle

L-Glutamate uptake by neurons
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015171
BFO_0000050: Glutamate Neurotransmitter Release Cycle
directly activates: L-Glutamate loading of synaptic vesicle
directly activates: Catalysis1645

Dopamine synaptic vesicle docking and priming
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: Restriction
  on property: BFO_0000066
  some values from: GO_0070083
type: GO_0000149
BFO_0000050: Dopamine Neurotransmitter Release Cycle
directly activates: Release of docked dopamine loaded synaptic vesicle
directly activates: Catalysis1650

Release of docked dopamine loaded synaptic vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: Dopamine Neurotransmitter Release Cycle

Transport of Choline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: CHT1
type: Restriction
  on property: enabled by
  some values from: CHT1
type: GO_0015220
BFO_0000050: Acetylcholine Neurotransmitter Release Cycle
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Catalysis1652

Cho is acetylated to AcCho by CHAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: GO_0004102
BFO_0000050: Acetylcholine Neurotransmitter Release Cycle
directly activates: Loading of acetylcholine in synaptic vesicle
directly activates: Catalysis1653
label: Synthesis of o-acetylcholine

Re-acidification of the clathrin sculpted acetylcholine transport vesicle
type: GO_0003674
BFO_0000050: Acetylcholine Neurotransmitter Release Cycle
directly activates: Loading of acetylcholine in synaptic vesicle
directly activates: Catalysis1653

Loading of acetylcholine in synaptic vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0060201
type: Restriction
  on property: BFO_0000066
  some values from: GO_0060201
type: Restriction
  on property: enabled by
  some values from: SLC18A3
type: Restriction
  on property: enabled by
  some values from: SLC18A3
type: GO_0005277
BFO_0000050: Acetylcholine Neurotransmitter Release Cycle
directly activates: Acetylcholine synaptic vesicle docking and priming
directly activates: Catalysis1654

Acetylcholine synaptic vesicle docking and priming
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000149
BFO_0000050: Acetylcholine Neurotransmitter Release Cycle
directly activates: Release of acetylcholine at the synapse
directly activates: Catalysis1655

Release of acetylcholine at the synapse
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: Acetylcholine Neurotransmitter Release Cycle

Synthesis of GABA by GAD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004351
BFO_0000050: GABA synthesis

Synthesis of GABA by GAD2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061202
type: GO_0004351
BFO_0000050: GABA synthesis

Loading of GABA into clathrin sculpted GABA transport vesicle lumen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061202
type: Restriction
  on property: enabled by
  some values from: SLC32A1
type: Restriction
  on property: enabled by
  some values from: SLC32A1
type: GO_0015171
BFO_0000050: GABA synthesis, release, reuptake and degradation
directly activates: GABA loaded synaptic vesicle Docking and Priming
directly activates: Catalysis1659

GABA loaded synaptic vesicle Docking and Priming
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061200
type: Restriction
  on property: BFO_0000066
  some values from: GO_0061200
type: GO_0000149
BFO_0000050: GABA synthesis, release, reuptake and degradation
directly activates: Release of GABA at the synapse
directly activates: Catalysis1660

Release of GABA at the synapse
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0000149
BFO_0000050: GABA synthesis, release, reuptake and degradation
directly activates: Catalysis1660

Conversion of GABA to Succinate Semialdehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0003867
BFO_0000050: Degradation of GABA

Conversion of succinate semialdehyde to succinate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: ALDH5A1
type: Restriction
  on property: enabled by
  some values from: ALDH5A1
type: Restriction
  on property: enabled by
  some values from: ALDH5A1
type: Restriction
  on property: enabled by
  some values from: ALDH5A1
type: GO_0004777
BFO_0000050: Degradation of GABA

Neurotransmitter Release Cycle
type: GO_0008150

Norepinephrine Neurotransmitter Release Cycle
type: GO_0008150
BFO_0000050: Neurotransmitter Release Cycle

Serotonin Neurotransmitter Release Cycle
type: GO_0008150
BFO_0000050: Neurotransmitter Release Cycle

Glutamate Neurotransmitter Release Cycle
type: GO_0008150
BFO_0000050: Neurotransmitter Release Cycle

Dopamine Neurotransmitter Release Cycle
type: GO_0008150
BFO_0000050: Neurotransmitter Release Cycle

Acetylcholine Neurotransmitter Release Cycle
type: GO_0008150
BFO_0000050: Neurotransmitter Release Cycle

GABA synthesis, release, reuptake and degradation
type: GO_0008150
BFO_0000050: Neurotransmitter Release Cycle

GABA synthesis
type: GO_0008150
BFO_0000050: GABA synthesis, release, reuptake and degradation

Reuptake of GABA
type: GO_0008150
BFO_0000050: GABA synthesis, release, reuptake and degradation

Degradation of GABA
type: GO_0008150
BFO_0000050: GABA synthesis, release, reuptake and degradation