PDK1
PDPK1
UniProt:O15530 PDPK1
IK1
IKCA1
KCA4
KCNN4
SK4
UniProt:O15554 KCNN4
RAF
RAF1
UniProt:P04049 RAF1
COMT
UniProt:P21964 COMT
PRKACB
UniProt:P22694 PRKACB
CHAT
UniProt:P28329 CHAT
ERK2
MAPK1
PRKM1
PRKM2
UniProt:P28482 MAPK1
NSF
UniProt:P46459 NSF
SLC6A12
UniProt:P48065 SLC6A12
ALDH5A1
SSADH
UniProt:P51649 ALDH5A1
DAT1
SLC6A3
UniProt:Q01959 SLC6A3
SLC18A2
SVMT
UniProt:Q05940 SLC18A2
VMAT2
SLC18A3
UniProt:Q16572 SLC18A3
VACHT
CAMKK1
CAMKKA
UniProt:Q8N5S9 CAMKK1
ATA2
KIAA1382
SAT2
SLC38A2
SNAT2
UniProt:Q96QD8 SLC38A2
CHT1
SLC5A7
UniProt:Q9GZV3 SLC5A7
ATA1
NAT2
SAT1
SLC38A1
SNAT1
UniProt:Q9H2H9 SLC38A1
SLC32A1
UniProt:Q9H598 SLC32A1
VGAT
VIAAT
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
GAT1-3 mediate Na+/Cl- dependent GABA transport
Uptake of Noradrenaline
Reuptake of dopamine from the synaptic celft into neurons
Reuptake of dopamine from the synaptic cleft into neurons
Reuptake of serotonin from the synapse
2GABRA:2GABRB:GABRG:GABA transports extracellular Cl- to cytosol
GABRR pentamer:GABA transports extracellular Cl- to cytosol
Binding of BoNT toxins to gut epithelial membrane
Transcytosis and internalization of BoNT
Conformational change in BoNT induced by pH
Pore or channel formation in endosomal membrane
Transportation of BoNT Light chain to cytosol
BoNT Light Chain Type B cleaves VAMP-2
BoNT Light Chain Type D cleaves VAMP
BoNT Light Chain Type F cleaves VAMP
BoNT Light Chain Type A cleaves SNAP-25
BoNT Light Chain Type C1 cleaves SNAP-25
BoNT Light Chain Type E cleaves SNAP-25
BoNT Light Chain Type C1 cleaves Syntaxin
Connexin 36 mediated neuronal gap junction communication
Connexin 45/Connexin 36 mediated neuronal gap junction communication
Connexin 62 mediated neuronal gap junction communication
Pannexin 1/Pannexin2 mediated neuronal gap junction communication
Ca2+ influx through voltage gated Ca2+ channels
Re-acidification of clathrin sculpted monoamine tranport vesicle lumen
Loading of dopamine into synaptic veiscles
Noradrenalin synaptic vesicle docking and priming
Release of noradrenaline at the synapse
Metabolism of Noradrenaline
loading of Serotonin in synaptic vesicles
Serotonin loaded synaptic vesicle docking and priming
Release of docked serotonin loaded synaptic vesicle
L-Glutamine transport into neurons
Transport of L-Glutamine (cytosol) to mitochondrial matrix
glutamine + H2O => glutamate + NH4+ [GLS]
Tranport of L-Glutamate (mitochondrial matrix) to cytosol
L-Glutamate loading of synaptic vesicle
Glutamate synaptic vesicle docking and priming
release of L-Glutamate at the synapse
L-Glutamate uptake by neurons
Dopamine synaptic vesicle docking and priming
Release of docked dopamine loaded synaptic vesicle
Transport of Choline
Cho is acetylated to AcCho by CHAT
Synthesis of o-acetylcholine
Re-acidification of the clathrin sculpted acetylcholine transport vesicle
Loading of acetylcholine in synaptic vesicle
Acetylcholine synaptic vesicle docking and priming
Release of acetylcholine at the synapse
Synthesis of GABA by GAD1
Synthesis of GABA by GAD2
Loading of GABA into clathrin sculpted GABA transport vesicle lumen
GABA loaded synaptic vesicle Docking and Priming
Release of GABA at the synapse
Conversion of GABA to Succinate Semialdehyde
Conversion of succinate semialdehyde to succinate
AcCho is hydrolyzed to Cho and acetate by ACHE
Acetylcholine clearance from synaptic cleft
Noradrenaline clearance from the synaptic cleft
methylation of Dopamine to form 3-Methoxytyramine
Oxidation of 3-Methoxytyramine to homovanillic acid
oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
Oxidative deamination of 5-Hydroxytryptamine by MAOA
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid
glutamate uptake by astrocytes
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
Glutamine transport from astrocytes
Binding of acetylcholine to highly calcium permeable acetylcholine receptors
Activation of highly calcium permeable nicotinic acetylcholine receptors
Binding of acetylcholine to highly sodium permeable acetylcholine receptors
Activation of highly sodium permeable nicotinic acetylcholine receptors
Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Trafficking of GluR1-containing AMPA receptors
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
Trafficking of GluR2-containing AMPA receptors to synapse
Endocytosis of Ca impermeable AMPA receptors
Ca permeable AMPA receptor ligand binding
Activation of Ca permeable AMPA receptors
Ca impermeable AMPA receptor ligand binding
Activation of Ca impermeable AMPA receptors
Membrane depolarization upon activation of Ca impermeable AMPA receptors
Unblocking of NMDA receptor
Glutamate binding to NMDA receptor
Activation of NMDA Receptor
Activation of RasGRF
Ras activation
Raf activation
Activation of MAPK
Phosphorylation by MAPK/ERK
Phophorylation by PDK1
Phosphorylation of CREB by ribosomal protein S6 kinase
Activation of Adenylate Cyclase
Phosphorylation of CREB by PKA
Activation of CaMKII
CaMKII enters cytoplasm
CaMKII enters nucleus
Phosphorylation of CREB by CaMKII
Activation of CaMKK
Phosphorylation of CREB by CaMKIV
Edited Kainate Receptor binds glutamate
Activation of Edited Kainate receptors
kainate receptor binds glutamate
Activation of Ca-permeable Kainate receptors
GRIK3 homomer binds glutamate
Activation of GRIK3 homomer
GABAB heterodimeric receptor binds GABA
G alpha (i) inhibits adenylate cyclase
G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
Adenylate cyclase increases the GTPase activity of G alpha-olf
Adenylate cyclase increases the GTPase activity of Gi alpha
Dissociation of the Gi alpha:G olf complex
Activation of GIRK/Kir3 Channels
Activation of Ca2+ activated Potassium channels with large conductance
Activation of Ca2+ activated Potassium channels with Intermeidtance conductance
Activation of Ca2+ activated Potassium channels with small conductance
Binding of cAMP to HCN channels
Activation of HCN channels
Activation of Potassium transport channels
Activation of ATP sensitive Potassium channels in neuroendocrine cells
Activation of ATP sensitive Potassium channels in muscle cells
Activation of classical Kir channels
Activation of voltage gated Potassium channels
Activation of tandem pore domain in a weak inwardly rectifying K+ channels
Activation of TWIK-related K+ channel (TREK)
Activation of TASK
Activation of TALK
Activation of TRESK
Activation of THIK
Botulinum neurotoxicity
Neurotoxicity of Botulinum toxins
Translocation of BoNT Light chain
Proteolytic cleavage of SNARE complex proteins
BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin
BoNT Light Chain Types A, C1, E cleave SNAP-25
Neuronal System
Transmission across Electrical Synapses
Electric Transmission Across Gap Junctions
Transmission across Chemical Synapses
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Serotonin Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
GABA synthesis, release, reuptake and degradation
GABA synthesis
Reuptake of GABA
Degradation of GABA
Neurotransmitter Clearance In The Synaptic Cleft
Clearance of dopamine
Dopamine clearance from the synaptic cleft
Enzymatic degradation of dopamine by COMT
Enzymatic degradation of Dopamine by monoamine oxidase
Clearance of seratonin
Clearance of serotonin
Serotonin clearance from the synaptic cleft
Metabolism of seratonin
Metabolism of serotonin
Neurotransmitter uptake and Metabolism In Glial Cells
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Acetylcholine Binding And Downstream Events
Activation of Nicotinic Acetylcholine Receptors
Presynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
Highly sodium permeable acetylcholine nicotinic receptors
Postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Activation of AMPA receptors
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Unblocking of NMDA receptor, glutamate binding and activation
Post NMDA receptor activation events
CREB phosphorylation through the activation of Ras
Ras activation uopn Ca2+ infux through NMDA receptor
RSK activation
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of CaMKK
Activation of CaMK IV
Activation of Kainate Receptors upon glutamate binding
Ionotropic activity of Kainate Receptors
Activation of Na-permeable Kainate Receptors
Activation of Ca-permeable Kainate Receptor
Presynaptic function of Kainate receptors
GABA receptor activation
GABA A receptor activation
GABA B receptor activation
Activation of GABAB receptors
Inhibition of adenylate cyclase pathway
Adenylate cyclase inhibitory pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GABA A (rho) receptor activation
Potassium Channels
Ca activated K+ channels
Ca2+ activated K+ channels
HCN channels
Inwardly rectifying K+ channels
G protein gated Potassium channels
Activation of G protein gated Potassium channels
Potassium transport channels
ATP sensitive Potassium channels
Classical Kir channels
Voltage gated Potassium channels
Tandem pore domain potassium channels
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
TWIK related potassium channel (TREK)
TWIK-releated acid-sensitive K+ channel (TASK)
TWIK-related alkaline pH activated K+ channel (TALK)
TWIK-related spinal cord K+ channel (TRESK)
Tandem pore domain halothane-inhibited K+ channel (THIK)