DICER
label: DICER1
label: HERNA
label: KIAA0928
label: UniProt:Q9UPY3 DICER1

Microprocessor complex cleaves pri-miRNA to pre-miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004525
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Exportin-5 recognizes 3' overhang of pre-miRNA
directly activates: Catalysis198

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003723
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Exportin complex translocates pre-miRNA to cytosol
directly activates: Catalysis199

Exportin complex translocates pre-miRNA to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0051033
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Dicer cleaves pre-miRNA to yield duplex miRNA
directly activates: Catalysis200

Dicer cleaves pre-miRNA to yield duplex miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DICER
type: GO_0004525
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Duplex miRNA is loaded into Argonaute
directly activates: BiochemicalReaction555

Duplex miRNA is loaded into Argonaute
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Removal of miRNA passenger strand

Removal of miRNA passenger strand
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: BiochemicalReaction554

MicroRNA (miRNA) Biogenesis
type: GO_0008150

Pol II mediated transcription of microRNA genes
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Microprocessor complex cleaves pri-miRNA to pre-miRNA
directly activates: Catalysis197