LCAT
label: UniProt:P04180 LCAT

ABCG1-mediated transport of intracellular cholesterol to the cell surface
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0017127
BFO_0000050: HDL-mediated lipid transport
directly activates: Discoidal HDL binds membrane-associated free cholesterol
directly activates: Spherical HDL binds membrane-associated free cholesterol and phospholipids
directly activates: Control384

ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0005319
type: GO_0042158
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
directly activates: Control376

ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
type: GO_0042158
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: Exocytosis of nascent chylomicrons
directly activates: Control377

Exocytosis of nascent chylomicrons
type: GO_0042158
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
label: nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
type: GO_0003674
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
directly activates: Catalysis2081
directly activates: Control378
directly activates: Control379
directly activates: Control380

chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004465
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III

TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III
type: GO_0003674
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: chylomicron remnant + apoE => chylomicron remnant:apoE complex

chylomicron remnant + apoE => chylomicron remnant:apoE complex
type: GO_0042159
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
directly activates: Control381

chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
type: GO_0006898
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
directly activates: Control382

chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
type: GO_0003674
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]

chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]
type: GO_0006898
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR

chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR
type: GO_0006898
BFO_0000050: Chylomicron-mediated lipid transport
directly activates: LDLR [endosome membrane] => LDLR [plasma membrane]

Conversion of pro-apoA-I to apoA-I
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004222
BFO_0000050: HDL-mediated lipid transport
directly activates: ABCA1 tetramer binds apoA-I

ABCA1 tetramer binds apoA-I
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: ABCA1-mediated transport of intracellular cholesterol to the cell surface
directly activates: ABCA1-mediated transport of intracellular phospholipid to the cell surface
directly activates: Catalysis2083
directly activates: Catalysis2084

ABCA1-mediated transport of intracellular cholesterol to the cell surface
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0017127
BFO_0000050: HDL-mediated lipid transport
directly activates: Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
directly activates: pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

ABCA1-mediated transport of intracellular phospholipid to the cell surface
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005548
BFO_0000050: HDL-mediated lipid transport
directly activates: Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
directly activates: pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: Discoidal HDL binds membrane-associated free cholesterol
directly activates: LCAT + discoidal HDL <=> LCAT:discoidal HDL complex

pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

Discoidal HDL binds membrane-associated free cholesterol
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

LCAT + discoidal HDL <=> LCAT:discoidal HDL complex
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: LCAT:discoidal HDL complex <=> LCAT + discoidal HDL

LCAT:discoidal HDL complex <=> LCAT + discoidal HDL
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

Spherical HDL binds C and E apolipoproteins
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

Spherical HDL binds membrane-associated free cholesterol and phospholipids
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: enabled by
  some values from: LCAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004607
BFO_0000050: HDL-mediated lipid transport
directly activates: 2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex

2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
label: Serum albumin binds 2-lysophosphatidylcholine

LCAT + spherical HDL <=> LCAT:spherical HDL complex
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: LCAT:spherical HDL complex <=> LCAT + spherical HDL

LCAT:spherical HDL complex <=> LCAT + spherical HDL
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: CETP-mediated lipid exchange: LDL gains cholesterol ester
label: CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol

CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

spherical HDL and SR-BI receptor form a complex at the cell surface
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: Disassembly of SR-BI-bound spherical HDL

Disassembly of SR-BI-bound spherical HDL
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

apoA-I binds to CUBN:AMN
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport
directly activates: Endocytosis and degradation of apoA-I

CETP-mediated lipid exchange: LDL gains cholesterol ester
type: GO_0003674
BFO_0000050: LDL endocytosis
directly activates: CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
label: CETP:cholesterol ester complex + LDL <=> LDL:cholesterol ester complex + CETP:triacylglycerol complex

apolipoprotein(a) + LDL => Lp(a)
type: GO_0042157
BFO_0000050: LDL endocytosis

LDL + LDLR => LDL:LDLR complex
type: GO_0006898
BFO_0000050: LDL endocytosis
directly activates: Internalization of LDL:LDLR complex (LDLRAP1-dependent)
directly activates: Internalization of LDL:LDLR complex (LDLRAP1-independent)
directly activates: Control386

Internalization of LDL:LDLR complex (LDLRAP1-dependent)
type: GO_0006898
BFO_0000050: LDL endocytosis
directly activates: LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
label: LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)

Internalization of LDL:LDLR complex (LDLRAP1-independent)
type: GO_0006898
BFO_0000050: LDL endocytosis
directly activates: LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
label: LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)

LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
type: GO_0006898
BFO_0000050: LDL endocytosis
directly activates: Dissociation of the LDL:LDLR complex in the early endosome
label: Movement of LDL:LDLR complex to early endosome

Dissociation of the LDL:LDLR complex in the early endosome
type: GO_0006898
BFO_0000050: LDL endocytosis
directly activates: LDLR [endosome membrane] => LDLR [plasma membrane]
label: LDLR:LDL complex => LDLR + LDL

LDLR [endosome membrane] => LDLR [plasma membrane]
type: GO_0006898
BFO_0000050: LDL endocytosis
directly activates: chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
directly activates: LDL + LDLR => LDL:LDLR complex
directly activates: Control381
label: Recycling of LDLR to plasma membrane

Degradation of newly synthesized ApoB-48
type: GO_0044257
BFO_0000050: Chylomicron-mediated lipid transport

Endocytosis and degradation of apoA-I
type: GO_0003674
BFO_0000050: HDL-mediated lipid transport

Lipoprotein metabolism
type: GO_0008150

Chylomicron-mediated lipid transport
type: GO_0008150
BFO_0000050: Lipoprotein metabolism

HDL-mediated lipid transport
type: GO_0008150
BFO_0000050: Lipoprotein metabolism

LDL endocytosis
type: GO_0008150
BFO_0000050: Lipoprotein metabolism
label: LDL-mediated lipid transport