LCAT
UniProt:P04180 LCAT
PLRP2
PNLIPRP2
UniProt:P54317 PNLIPRP2
MGLL
UniProt:Q99685 MGLL
NPC1L1
UniProt:Q9UHC9-2 NPC1L1
ABCG5:ABCG8-mediated export of cholesterol and phytosterols
sterols[cytosol] + ATP => sterols[extracellular] + ADP + Pi
ABCG1-mediated transport of intracellular cholesterol to the cell surface
Digestion of retinyl palmitate by extracellular PTL:colipase
PNLIP:CLPS hydrolyses RPALM to atROL and PALM
Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)
Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)
Digestion of diacylglycerols by extracellular PTL:colipase
Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)
Digestion of triacylglycerols by extracellular PTL:colipase
Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2
NPC1L1-mediated cholesterol uptake
NPC1L1-mediated phytosterol uptake
NPC1L1 + ezetimibe => NPC1L1:ezetimibe complex
NPC1L1 inactivation by ezetimibe
ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex
ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
Exocytosis of nascent chylomicrons
nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III
chylomicron remnant + apoE => chylomicron remnant:apoE complex
chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]
chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR
Conversion of pro-apoA-I to apoA-I
ABCA1 tetramer binds apoA-I
ABCA1-mediated transport of intracellular cholesterol to the cell surface
ABCA1-mediated transport of intracellular phospholipid to the cell surface
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
Discoidal HDL binds membrane-associated free cholesterol
LCAT + discoidal HDL <=> LCAT:discoidal HDL complex
LCAT:discoidal HDL complex <=> LCAT + discoidal HDL
Spherical HDL binds C and E apolipoproteins
Spherical HDL binds membrane-associated free cholesterol and phospholipids
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex
Serum albumin binds 2-lysophosphatidylcholine
LCAT + spherical HDL <=> LCAT:spherical HDL complex
LCAT:spherical HDL complex <=> LCAT + spherical HDL
CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol
CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex
spherical HDL and SR-BI receptor form a complex at the cell surface
Disassembly of SR-BI-bound spherical HDL
apoA-I binds to CUBN:AMN
CETP-mediated lipid exchange: LDL gains cholesterol ester
CETP:cholesterol ester complex + LDL <=> LDL:cholesterol ester complex + CETP:triacylglycerol complex
apolipoprotein(a) + LDL => Lp(a)
LDL + LDLR => LDL:LDLR complex
Internalization of LDL:LDLR complex (LDLRAP1-dependent)
LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
Internalization of LDL:LDLR complex (LDLRAP1-independent)
LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)
LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
Movement of LDL:LDLR complex to early endosome
Dissociation of the LDL:LDLR complex in the early endosome
LDLR:LDL complex => LDLR + LDL
LDLR [endosome membrane] => LDLR [plasma membrane]
Recycling of LDLR to plasma membrane
hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
2 phosphorylated HSL monomers -> phosphorylated HSL dimer
perilipin:CGI-58 complex -> perilipin + CGI-58
perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
Phosphorylated HSL dimer translocates from the cytosol to the lipid particle
phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex
cholesterol ester + H2O -> cholesterol + fatty acid
triacylglycerol + H2O -> diacylglycerol + fatty acid
diacylglycerol + H2O -> 2-acylglycerol + fatty acid
2-acylglycerol + H2O -> glycerol + fatty acid
phosphorylated HSL + H2O -> HSL + orthophosphate
phosphorylated perilipin + H2O -> perilipin + orthophosphate
Degradation of newly synthesized ApoB-48
Endocytosis and degradation of apoA-I
Lipid and lipoprotein metabolism
Lipid digestion, mobilization, and transport
Digestion of dietary lipid
Trafficking of dietary sterols
Lipoprotein metabolism
Chylomicron-mediated lipid transport
HDL-mediated lipid transport
LDL endocytosis
LDL-mediated lipid transport
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis