FADS1
label: FADSD5
label: UniProt:O60427 FADS1

FADS2
label: UniProt:O95864 FADS2

ABCD1
label: ALD
label: UniProt:P33897 ABCD1

ELOVL2
label: SSC2
label: UniProt:Q9NXB9 ELOVL2

ELOVL2
label: ELOVL5
label: PRO0530
label: UniProt:Q9NYP7 ELOVL5

Activation of linoleic acid to linoleoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
directly activates: Catalysis2446

Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FADS2
type: GO_0016213
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
directly activates: Catalysis2447

Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
directly activates: Catalysis2448

Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA
type: Restriction
  on property: enabled by
  some values from: FADS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0045485
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
directly activates: Catalysis2449

Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
directly activates: Catalysis2450
label: arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]

Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
type: Restriction
  on property: enabled by
  some values from: ELOVL2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0009922
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
directly activates: Catalysis2451

Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
type: Restriction
  on property: enabled by
  some values from: FADS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016213
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Translocation of tetracosapentaenoyl-CoA to peroxisomes
directly activates: Catalysis2452

Translocation of tetracosapentaenoyl-CoA to peroxisomes
type: Restriction
  on property: enabled by
  some values from: ABCD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0005324
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA

Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA
type: GO_0003674
BFO_0000050: Linoleic acid (LA) metabolism
directly activates: Translocation of DPA to the ER

Translocation of DPA to the ER
type: GO_0003674
BFO_0000050: Linoleic acid (LA) metabolism

Linoleic acid (LA) metabolism
type: GO_0008150