SRC
label: SRC1
label: UniProt:P12931-1 SRC

ERK2
label: MAPK1
label: PRKM1
label: PRKM2
label: UniProt:P28482 MAPK1

DRT
label: EPHB2
label: EPHT3
label: EPTH3
label: ERK
label: HEK5
label: TYRO5
label: UniProt:P29323 EPHB2

UniProt:P52735 VAV2
label: VAV2

PAK1
label: UniProt:Q13153 PAK1

Phosphorylation of L1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Recycling pathway of L1
directly activates: L1 binds ERM family members

L1 binds ERM family members
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: L1 trans-homophilic interaction

L1 trans-homophilic interaction
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Linkage of L1 with treadmilling F-actin

Linkage of L1 with treadmilling F-actin
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Dephosphorylation of pL1 (Y1176)
directly activates: Catalysis3200

Shootin-1 links L1 and retrograde actin flow
type: GO_0003674
BFO_0000050: Recycling pathway of L1

Dephosphorylation of pL1 (Y1176)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Recycling pathway of L1
directly activates: L1 binds to AP-2 Clathrin complex

L1 binds to AP-2 Clathrin complex
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Formation of clathrin coated vesicle
directly activates: Transport of L1 into endosomes
directly activates: Catalysis3201

Formation of clathrin coated vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: Recycling pathway of L1

Interaction of NUMB with L1
type: GO_0003674
BFO_0000050: Recycling pathway of L1

Transport of L1 into endosomes
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Phosphorylation of L1 by p90rsk
directly activates: Phosphorylation of L1 by ERK
directly activates: Transport of L1 from C-domain to P-domain
directly activates: Catalysis3202
directly activates: Catalysis3203

Phosphorylation of L1 by p90rsk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Recycling pathway of L1
BFO_0000050: Signal transduction by L1

Phosphorylation of L1 by ERK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Recycling pathway of L1
BFO_0000050: Signal transduction by L1

Transport of L1 from C-domain to P-domain
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Reinsertion of L1 into the plasma membrane

Reinsertion of L1 into the plasma membrane
type: GO_0003674
BFO_0000050: Recycling pathway of L1
directly activates: Phosphorylation of L1 by SRC
directly activates: Catalysis3199

L1 dimer binds Ankyrin
type: GO_0003674
BFO_0000050: Interaction between L1 and Ankyrins

L1 linked to actin cytoskeleton by ankyrin
type: GO_0003674
BFO_0000050: Interaction between L1 and Ankyrins

Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1
type: GO_0003674
BFO_0000050: Interaction between L1 and Ankyrins

Phosphorylation of Y1229 in L1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Interaction between L1 and Ankyrins

L1 and NCAM1 engaged in cis-interaction
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1-FGFR cis-heterodimerization
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1-EGFR trans-heterodimerization
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1 binds NRP1
type: GO_0003674
BFO_0000050: Signal transduction by L1

L1 interaction with Integrins
type: GO_0003674
BFO_0000050: Signal transduction by L1

Phosphorylation of VAV2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signal transduction by L1
directly activates: Activation of Rac1 by VAV2
directly activates: Catalysis3206

Activation of Rac1 by VAV2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: Restriction
  on property: enabled by
  some values from: UniProt:P52735 VAV2
type: GO_0005085
BFO_0000050: Signal transduction by L1
directly activates: Interaction of PAK1 with Rac1-GTP
directly activates: Catalysis3207

Interaction of PAK1 with Rac1-GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PAK1
type: Restriction
  on property: enabled by
  some values from: PAK1
type: GO_0004674
BFO_0000050: Signal transduction by L1

Phosphorylation of L1 by CK-II
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signal transduction by L1

Interaction of L1 with Neurocan
type: GO_0003674
BFO_0000050: L1CAM interactions

Interaction of L1 with Laminin-1
type: GO_0003674
BFO_0000050: L1CAM interactions

Cis-heterodimerization of L1 and Axonin-1
type: GO_0003674
BFO_0000050: L1CAM interactions

Cis-heterodimerization of L1 and Contactin-1/F3/F11
type: GO_0003674
BFO_0000050: L1CAM interactions

Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN
type: GO_0003674
BFO_0000050: L1CAM interactions

L1 binds RanBPM
type: GO_0003674
BFO_0000050: L1CAM interactions

Heat-Stable Antigen binds L1
type: GO_0003674
BFO_0000050: L1CAM interactions

Phosphorylation of L1 by EPHB2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: DRT
type: GO_0004713
BFO_0000050: L1CAM interactions

CHL1 interacts with Ankyrin-G
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with HSP7C
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with NRP1
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with beta1 integrins
type: GO_0003674
BFO_0000050: CHL1 interactions

CHL1 interacts with contactin-6
type: GO_0003674
BFO_0000050: CHL1 interactions

Neurofascin binds Ankyrin-G
type: GO_0003674
BFO_0000050: Neurofascin interactions
directly activates: Trans-homodimerization of Neurofascin

Trans-homodimerization of Neurofascin
type: GO_0003674
BFO_0000050: Neurofascin interactions

Neurofascin and NrCAM heterodimerization
type: GO_0003674
BFO_0000050: Neurofascin interactions

Phosphorylation of Neurofascin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Neurofascin interactions

Doublecortin binds phosphorylated neurofascin
type: GO_0003674
BFO_0000050: Neurofascin interactions

Neurofascin interacts with syntenin-1
type: GO_0003674
BFO_0000050: Neurofascin interactions

Neurofascin binds contactin-1:CASPR complex
type: GO_0003674
BFO_0000050: Neurofascin interactions

NrCAM binds Ankyrin-G
type: GO_0003674
BFO_0000050: NrCAM interactions

NrCAM binds axonin-1
type: GO_0003674
BFO_0000050: NrCAM interactions

NrCAM binds synapse-associated proteins
type: GO_0003674
BFO_0000050: NrCAM interactions

NrCAM binds Neuropilin-2
type: GO_0003674
BFO_0000050: NrCAM interactions

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Signal transduction by L1
directly activates: BiochemicalReaction897

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Signal transduction by L1
directly activates: BiochemicalReaction902

L1CAM interactions
type: GO_0008150

Recycling pathway of L1
type: GO_0008150
BFO_0000050: L1CAM interactions

Interaction between L1 and Ankyrins
type: GO_0008150
BFO_0000050: L1CAM interactions

Signal transduction by L1
type: GO_0008150
BFO_0000050: L1CAM interactions

CHL1 interactions
type: GO_0008150
BFO_0000050: L1CAM interactions

Neurofascin interactions
type: GO_0008150
BFO_0000050: L1CAM interactions

NrCAM interactions
type: GO_0008150
BFO_0000050: L1CAM interactions