CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

p-RAF binds 14-3-3 beta/alpha
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Transient dissociation of 14-3-3 upon Ras binding

Transient dissociation of 14-3-3 upon Ras binding
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAF by further phosphorylation
directly activates: Catalysis447

Stabilisation of RAF by further phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: RAF activation
directly activates: Activated RAF1 complex binds MEK

Phosphorylated human RAF1 binds to RAS:GTP complex
type: GO_0003674
BFO_0000050: RAF activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

Activated RAF1 complex binds MEK
type: GO_0003674
BFO_0000050: MEK activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

RAF1 phosphorylates MEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK1 binds ERK-1

RAF1 phosphorylates MEK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK2 binds ERK-2

IL2RB associates with JAK1
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

IL2RG associates with JAK3
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
directly activates: BiochemicalReaction1507

Interleukin-2 receptor alpha binds interleukin-2
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit

Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Within the IL-2R complex JAK3 phosphorylates JAK1
directly activates: Catalysis519

Within the IL-2R complex JAK3 phosphorylates JAK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interleukin-2 signaling
directly activates: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
directly activates: Syk binds IL2RB
directly activates: Pyk2 associates with Jak3
directly activates: Catalysis520

JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interleukin-2 signaling
directly activates: Phosphorylation of IL2RB Y338 enables SHC recruitment
directly activates: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment

Phosphorylation of IL2RB Y338 enables SHC recruitment
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: SHC1 bound to IL2 receptor is phosphorylated
directly activates: Catalysis521

Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Recruited STAT5 is phosphorylated
directly activates: Catalysis523

SHC1 bound to IL2 receptor is phosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Interleukin-2 signaling
directly activates: Phosphorylated SHC1 recruits GRB2:GAB2
directly activates: Phosphorylated SHC recruits GRB2:SOS1

Phosphorylated SHC1 recruits GRB2:GAB2
type: GO_0003674
BFO_0000050: Interleukin receptor SHC signaling
directly activates: SHC1 mediates cytokine-induced phosphorylation of GAB2

SHC1 mediates cytokine-induced phosphorylation of GAB2
type: GO_0003674
BFO_0000050: Interleukin receptor SHC signaling
directly activates: Gab2 binds the p85 subunit of Class 1A PI3 kinases

Gab2 binds the p85 subunit of Class 1A PI3 kinases
type: GO_0003674
BFO_0000050: Interleukin receptor SHC signaling

Phosphorylated SHC recruits GRB2:SOS1
type: GO_0003674
BFO_0000050: Interleukin receptor SHC signaling
directly activates: SOS1 activates H-Ras
directly activates: BiochemicalReaction3817
directly activates: Catalysis1738
directly activates: Catalysis522

SOS1 activates H-Ras
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Interleukin receptor SHC signaling
directly activates: Transient dissociation of 14-3-3 upon Ras binding
directly activates: Phosphorylated human RAF1 binds to RAS:GTP complex

Phosphorylated SHC1 recruits SHIP
type: GO_0003674
BFO_0000050: Interleukin receptor SHC signaling
directly activates: The SHC1:SHIP1 complex is stabilized by GRB2

The SHC1:SHIP1 complex is stabilized by GRB2
type: GO_0003674
BFO_0000050: Interleukin receptor SHC signaling

Recruited STAT5 is phosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interleukin-2 signaling
directly activates: Phosphorylated STAT5 is released

Phosphorylated STAT5 is released
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Phosphorylated STAT5 forms dimers

Phosphorylated STAT5 forms dimers
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: STAT5 dimers translocate to the nucleus and bind to specific DNA sequences

STAT5 dimers translocate to the nucleus and bind to specific DNA sequences
type: GO_0003674
BFO_0000050: Interleukin-2 signaling

Syk binds IL2RB
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: SYK is a substrate for JAK1
directly activates: Catalysis524

SYK is a substrate for JAK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interleukin-2 signaling

Pyk2 associates with Jak3
type: GO_0003674
BFO_0000050: Interleukin-2 signaling
directly activates: Pyk2 is activated following IL2 stimulation

Pyk2 is activated following IL2 stimulation
type: GO_0003674
BFO_0000050: Interleukin-2 signaling

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

ERK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

RAF/MAP kinase cascade
type: GO_0008150
BFO_0000050: Interleukin-2 signaling

RAF activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

MEK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

RAF phosphorylates MEK
type: GO_0008150
BFO_0000050: MEK activation

Interleukin-2 signaling
type: GO_0008150

Interleukin receptor SHC signaling
type: GO_0008150
BFO_0000050: Interleukin-2 signaling