CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
IL2RB associates with JAK1
IL2RG associates with JAK3
Interleukin-2 receptor alpha binds interleukin-2
Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
Within the IL-2R complex JAK3 phosphorylates JAK1
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
Phosphorylation of IL2RB Y338 enables SHC recruitment
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
SHC1 bound to IL2 receptor is phosphorylated
Phosphorylated SHC1 recruits GRB2:GAB2
SHC1 mediates cytokine-induced phosphorylation of GAB2
Gab2 binds the p85 subunit of Class 1A PI3 kinases
Phosphorylated SHC recruits GRB2:SOS1
SOS1 activates H-Ras
Phosphorylated SHC1 recruits SHIP
The SHC1:SHIP1 complex is stabilized by GRB2
Recruited STAT5 is phosphorylated
Phosphorylated STAT5 is released
Phosphorylated STAT5 forms dimers
STAT5 dimers translocate to the nucleus and bind to specific DNA sequences
Syk binds IL2RB
SYK is a substrate for JAK1
Pyk2 associates with Jak3
Pyk2 is activated following IL2 stimulation
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
Interleukin-2 signaling
Interleukin receptor SHC signaling