Ficolin-1 binds to molecular patterns on the target cell surface
type: GO_0003674
BFO_0000050: Ficolins bind to repetitive carbohydrate structures on the target cell surface
directly activates: Activation of MASPs

Ficolin-2 binds to molecular patterns on the target cell surface
type: GO_0003674
BFO_0000050: Ficolins bind to repetitive carbohydrate structures on the target cell surface
directly activates: Activation of MASPs

Ficolin-3 binds to molecular patterns on the target cell surface
type: GO_0003674
BFO_0000050: Ficolins bind to repetitive carbohydrate structures on the target cell surface
directly activates: Activation of MASPs

MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
type: GO_0003674
BFO_0000050: Lectin pathway of complement activation
directly activates: Activation of MASPs

Activation of MASPs
type: GO_0003674
BFO_0000050: Lectin pathway of complement activation
directly activates: Conversion of C4 into C4a and C4b
directly activates: Conversion of C2 into C2a and C2b
directly activates: Catalysis383
directly activates: Catalysis384

Activation of C1R
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Classical antibody-mediated complement activation
directly activates: Activation of C1S
directly activates: Catalysis382

Activation of C1S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Classical antibody-mediated complement activation
directly activates: Conversion of C4 into C4a and C4b
directly activates: Catalysis383

Conversion of C4 into C4a and C4b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Initial triggering of complement
directly activates: C4b binds to cell surface
directly activates: BiochemicalReaction1059

C4b binds to cell surface
type: GO_0003674
BFO_0000050: Initial triggering of complement
directly activates: Formation of Classical C3 convertase (C4b:C2a complex)

Conversion of C2 into C2a and C2b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Initial triggering of complement
directly activates: Formation of Classical C3 convertase (C4b:C2a complex)

Formation of Classical C3 convertase (C4b:C2a complex)
type: GO_0003674
BFO_0000050: Initial triggering of complement
directly activates: BiochemicalReaction1028
directly activates: BiochemicalReaction1031
directly activates: BiochemicalReaction1043
directly activates: BiochemicalReaction1048
directly activates: Catalysis389

Spontaneous hydrolysis of C3 thioester
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor B binds to C3(H2O)

Factor B binds to C3(H2O)
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor D cleaves C3(H2O)-bound Factor B
directly activates: Catalysis385

Factor D cleaves C3(H2O)-bound Factor B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: C3(H2O):Factor Bb cleaves C3 to C3b and C3a
directly activates: BiochemicalReaction1035
directly activates: BiochemicalReaction1043
directly activates: BiochemicalReaction1048
directly activates: Catalysis386
directly activates: Control77

C3(H2O):Factor Bb cleaves C3 to C3b and C3a
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: C3b binds to cell surface

C3b binds to cell surface
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor B binds to surface-associated C3b
directly activates: BiochemicalReaction1034
directly activates: Control76

Factor B binds to surface-associated C3b
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor D cleaves C3b-bound Factor B
directly activates: Catalysis387

Factor D cleaves C3b-bound Factor B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: Properdin stabilizes C3b:Bb bound to cell surfaces
directly activates: BiochemicalReaction1035
directly activates: BiochemicalReaction1043
directly activates: BiochemicalReaction1048
directly activates: Control77

Properdin stabilizes C3b:Bb bound to cell surfaces
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Formation of alternative pathway C5 convertase
directly activates: BiochemicalReaction1028
directly activates: BiochemicalReaction1031
directly activates: Catalysis388
directly activates: Catalysis389

Formation of alternative pathway C5 convertase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: BiochemicalReaction1028
directly activates: BiochemicalReaction1030
directly activates: BiochemicalReaction1031
directly activates: Catalysis389
directly activates: Catalysis390

Initial triggering of complement
type: GO_0008150

Creation of C4 and C2 activators
type: GO_0008150
BFO_0000050: Initial triggering of complement

Lectin pathway of complement activation
type: GO_0008150
BFO_0000050: Creation of C4 and C2 activators

Ficolins bind to repetitive carbohydrate structures on the target cell surface
type: GO_0008150
BFO_0000050: Lectin pathway of complement activation

Classical antibody-mediated complement activation
type: GO_0008150
BFO_0000050: Creation of C4 and C2 activators

Alternative complement activation
type: GO_0008150
BFO_0000050: Initial triggering of complement