UBCH8
UBE2L6
UniProt:O14933 UBE2L6
UBA7
UBE1L
UBE2
UniProt:P41226 UBA7
ISG43
USP18
UniProt:Q9UMW8 USP18
PIN1 mediated IRF3 degradation
Activation of ISG15 by UBE1L E1 ligase
Transfer of ISG15 from E1 to E2 (UBCH8)
Interaction of E3 ligase with ISG15:E2 complex
ISGylation of host proteins
ISGylation of host protein filamin B
ISGylation of protein phosphatase 1 beta (PP2CB)
ISGylation of E2 conjugating enzymes
Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
ISGylation of viral protein NS1
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
ISGylation of IRF3
ISGylation of protein translation regulator 4EHP
Competitive inhibition of translation initiation by ISGylated 4EHP
Monoubiquitination of N-myristoyl GAG (P12493) protein
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
ISG15 antiviral mechanism