UBCH8
label: UBE2L6
label: UniProt:O14933 UBE2L6

UBA7
label: UBE1L
label: UBE2
label: UniProt:P41226 UBA7

ISG43
label: USP18
label: UniProt:Q9UMW8 USP18

PIN1 mediated IRF3 degradation
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Activation of ISG15 by UBE1L E1 ligase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UBA7
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism
directly activates: Transfer of ISG15 from E1 to E2 (UBCH8)
directly activates: Catalysis501

Transfer of ISG15 from E1 to E2 (UBCH8)
type: Restriction
  on property: enabled by
  some values from: UBCH8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043130
BFO_0000050: ISG15 antiviral mechanism
directly activates: Interaction of E3 ligase with ISG15:E2 complex

Interaction of E3 ligase with ISG15:E2 complex
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism
directly activates: ISGylation of host proteins
directly activates: ISGylation of host protein filamin B
directly activates: ISGylation of protein phosphatase 1 beta (PP2CB)
directly activates: ISGylation of E2 conjugating enzymes
directly activates: ISGylation of viral protein NS1
directly activates: ISGylation of IRF3
directly activates: Catalysis502
directly activates: Catalysis503
directly activates: Catalysis504
directly activates: Catalysis505
directly activates: Catalysis506
directly activates: Catalysis508

ISGylation of host proteins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of host protein filamin B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of protein phosphatase 1 beta (PP2CB)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of E2 conjugating enzymes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

ISGylation of viral protein NS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: GO_0005487
type: GO_0075733
BFO_0000050: ISG15 antiviral mechanism

ISGylation of IRF3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of protein translation regulator 4EHP
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Competitive inhibition of translation initiation by ISGylated 4EHP
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Monoubiquitination of N-myristoyl GAG (P12493) protein
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ISG43
type: GO_0019785
BFO_0000050: ISG15 antiviral mechanism

ISG15 antiviral mechanism
type: GO_0008150