HAL
label: HIS
label: UniProt:P42357 HAL

AMDHD1
label: HMFT1272
label: UniProt:Q96NU7 AMDHD1

histidine => urocanate + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HAL
type: GO_0004397
BFO_0000050: Histidine catabolism
directly activates: urocanate + H2O => 4-imidazolone-5-propionate
directly activates: Catalysis2857

urocanate + H2O => 4-imidazolone-5-propionate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016153
BFO_0000050: Histidine catabolism
directly activates: 4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+
directly activates: Catalysis2858

4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AMDHD1
type: GO_0016812
BFO_0000050: Histidine catabolism
directly activates: N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate
directly activates: Catalysis2859

N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030412
BFO_0000050: Histidine catabolism

Histidine is decarboxylated to histamine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0001694
type: GO_0004398
BFO_0000050: Histidine catabolism

Histidine catabolism
type: GO_0008150