Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
Liganded G12/13-activating GPCR acts as a GEF for G12/13
The Ligand:GPCR:G12/13 complex dissociates
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
p115-RhoGEF activation of Rac1
Rac1 activation of PI3K
GEFs activate RhoA,B,C
ROCK activation by Rho
LARG activation by G alpha 12/13
LARG binds plexin B1
G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (12/13) reassociates with G beta:gamma
G alpha (12/13) signalling events