Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: Liganded G12/13-activating GPCR acts as a GEF for G12/13
directly activates: Catalysis1890

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (12/13) signalling events
directly activates: The Ligand:GPCR:G12/13 complex dissociates

The Ligand:GPCR:G12/13 complex dissociates
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
directly activates: LARG activation by G alpha 12/13
directly activates: G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1893

G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: p115-RhoGEF activation of Rac1
directly activates: GEFs activate RhoA,B,C
directly activates: Catalysis1891
directly activates: Catalysis1892

p115-RhoGEF activation of Rac1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (12/13) signalling events
directly activates: Rac1 activation of PI3K

Rac1 activation of PI3K
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: BiochemicalReaction2320
directly activates: Catalysis1027

GEFs activate RhoA,B,C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005089
BFO_0000050: G alpha (12/13) signalling events
directly activates: ROCK activation by Rho

ROCK activation by Rho
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: BiochemicalReaction6113
directly activates: BiochemicalReaction6114
directly activates: Catalysis3170
directly activates: Catalysis3171

LARG activation by G alpha 12/13
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events
directly activates: GEFs activate RhoA,B,C
directly activates: LARG binds plexin B1
directly activates: Catalysis1892

LARG binds plexin B1
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (12/13) signalling events
directly activates: Inactive G alpha (12/13) reassociates with G beta:gamma

Inactive G alpha (12/13) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (12/13) signalling events

G alpha (12/13) signalling events
type: GO_0008150