UniProt:P30291 WEE1
label: WEE1

PLK
label: PLK1
label: UniProt:P53350 PLK1

MYT1
label: PKMYT1
label: UniProt:Q99640 PKMYT1

Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
directly activates: Control139

Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis864

Formation of Cyclin A:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Myt-1 mediated phosphorylation of Cyclin A:Cdc2
directly activates: Catalysis853

Myt-1 mediated phosphorylation of Cyclin A:Cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MYT1
type: Restriction
  on property: enabled by
  some values from: MYT1
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus

Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
directly activates: Catalysis854

CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
directly activates: Catalysis855

Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
directly activates: Catalysis856

Translocation of active Cdc25C to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
directly activates: Catalysis856

Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
directly activates: Catalysis858
directly activates: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

Formation of Cyclin B:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes

Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
directly activates: Catalysis859

CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
directly activates: Phosphorylation of Cyclin B1 in the CRS domain
directly activates: Catalysis819
directly activates: Catalysis861

Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
directly activates: Catalysis860

Translocation of Cdc25B to the cytoplasm
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis860
directly activates: Catalysis864

Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Phosphorylation of Cyclin B1 in the CRS domain
directly activates: Catalysis861

Phosphorylation of Cyclin B1 in the CRS domain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes

Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
directly activates: Catalysis862

Translocation of Cdc25 to the nucleus
type: GO_0003674
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
directly activates: Catalysis862

Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Cyclin A/B1 associated events during G2/M transition
directly activates: Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes
directly activates: BiochemicalReaction1974
directly activates: BiochemicalReaction2020
directly activates: BiochemicalReaction2025
directly activates: BiochemicalReaction2027
directly activates: BiochemicalReaction2029
directly activates: Catalysis863
directly activates: Catalysis876
directly activates: Catalysis905
directly activates: Catalysis909
directly activates: Catalysis911

Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Cyclin A/B1 associated events during G2/M transition

Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004721
BFO_0000050: Cyclin B2 mediated events
directly activates: Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes
directly activates: Catalysis865

Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004693
BFO_0000050: Cyclin B2 mediated events

PLK1 phosphorylates OPTN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition
directly activates: Phosphorylated OPTN translocates to the nucleus

Phosphorylated OPTN translocates to the nucleus
type: GO_0003674
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition

Cytosolic PLK1 translocates to the nucleus
type: GO_0003674
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition

Myosin phosphatase dephosphorylates PLK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004722
BFO_0000050: Regulation of PLK1 Activity at G2/M Transition

Inactivation of Wee1 kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
type: GO_0051726
BFO_0000050: Polo-like kinase mediated events
directly activates: Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
directly activates: Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
directly activates: Catalysis856
directly activates: Catalysis862

Activation of Cdc25C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
type: GO_0051726
BFO_0000050: Polo-like kinase mediated events
directly activates: Translocation of Cdc25 to the nucleus
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis864

Inactivation of Myt1 kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
type: GO_0051726
BFO_0000050: Polo-like kinase mediated events
directly activates: Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
directly activates: Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
directly activates: Catalysis860
directly activates: Catalysis864

Recruitment of CDK11p58 to the centrosomes
type: GO_0003674
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Recruitment of Plk1 to centrosomes
type: GO_0003674
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Cyclin B/Cdk1 mediate phosphorylation of NuMA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Recruitment of NuMA to mitotic centrosomes

Translocation of NuMA to the centrosomes
type: GO_0003674
BFO_0000050: Recruitment of NuMA to mitotic centrosomes

Association of NuMA with microtubules
type: GO_0003674
BFO_0000050: Recruitment of NuMA to mitotic centrosomes

Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
type: GO_0003674
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Loss of C-Nap-1 from centrosomes
type: GO_0003674
BFO_0000050: Loss of proteins required for interphase microtubule organization from the centrosome

Plk1-mediated phosphorylation of Nlp
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: Restriction
  on property: enabled by
  some values from: PLK
type: GO_0004674
BFO_0000050: Loss of Nlp from mitotic centrosomes
directly activates: Dissociation of Phospho-Nlp from the centrosome

Dissociation of Phospho-Nlp from the centrosome
type: GO_0003674
BFO_0000050: Loss of Nlp from mitotic centrosomes

G2/M Transition
type: GO_0008150

Cyclin A/B1 associated events during G2/M transition
type: GO_0008150
BFO_0000050: G2/M Transition

Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
type: GO_0008150
BFO_0000050: Cyclin A/B1 associated events during G2/M transition

Cyclin B2 mediated events
type: GO_0008150
BFO_0000050: G2/M Transition

Regulation of PLK1 Activity at G2/M Transition
type: GO_0008150
BFO_0000050: G2/M Transition

Polo-like kinase mediated events
type: GO_0008150
BFO_0000050: G2/M Transition

Centrosome maturation
type: GO_0008150
BFO_0000050: G2/M Transition

Recruitment of mitotic centrosome proteins and complexes
type: GO_0008150
BFO_0000050: Centrosome maturation

Recruitment of NuMA to mitotic centrosomes
type: GO_0008150
BFO_0000050: Recruitment of mitotic centrosome proteins and complexes

Loss of proteins required for interphase microtubule organization from the centrosome
type: GO_0008150
BFO_0000050: Centrosome maturation

Loss of Nlp from mitotic centrosomes
type: GO_0008150
BFO_0000050: Loss of proteins required for interphase microtubule organization from the centrosome