UniProt:P30291 WEE1
WEE1
PLK
PLK1
UniProt:P53350 PLK1
MYT1
PKMYT1
UniProt:Q99640 PKMYT1
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
Formation of Cyclin A:Cdc2 complexes
Myt-1 mediated phosphorylation of Cyclin A:Cdc2
Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
Translocation of active Cdc25C to the nucleus
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes
Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
Formation of Cyclin B:Cdc2 complexes
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
Translocation of Cdc25B to the cytoplasm
Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
Phosphorylation of Cyclin B1 in the CRS domain
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
Translocation of Cdc25 to the nucleus
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes
Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes
PLK1 phosphorylates OPTN
Phosphorylated OPTN translocates to the nucleus
Cytosolic PLK1 translocates to the nucleus
Myosin phosphatase dephosphorylates PLK1
Inactivation of Wee1 kinase
Activation of Cdc25C
Inactivation of Myt1 kinase
Recruitment of CDK11p58 to the centrosomes
Recruitment of Plk1 to centrosomes
Cyclin B/Cdk1 mediate phosphorylation of NuMA
Translocation of NuMA to the centrosomes
Association of NuMA with microtubules
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Plk1-mediated phosphorylation of Nlp
Dissociation of Phospho-Nlp from the centrosome
G2/M Transition
Cyclin A/B1 associated events during G2/M transition
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Cyclin B2 mediated events
Regulation of PLK1 Activity at G2/M Transition
Polo-like kinase mediated events
Centrosome maturation
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes