DYRK
label: DYRK1A
label: MNB
label: MNBH
label: UniProt:Q13627 DYRK1A

Phosphorylation of LIN52 component of MuvB by DYRK1A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: DYRK
type: GO_0004672
BFO_0000050: G0 and Early G1
directly activates: p130 (RBL2) associates with MuvB to form DREAM complex

p130 (RBL2) associates with MuvB to form DREAM complex
type: GO_0003674
BFO_0000050: G0 and Early G1
directly activates: Transcription of E2F targets under negative control by DREAM complex
directly activates: Control134

Transcription of E2F targets under negative control by DREAM complex
type: GO_0003674
BFO_0000050: G0 and Early G1

HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
type: GO_0003674
BFO_0000050: G0 and Early G1
directly activates: Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
directly activates: Control135
directly activates: Control136
label: Recruitment of HDAC1 by p107 (RBL1)

HDAC1 + p130(RBL2):E2F4/5:DP1 => HDAC1-p130(RBL2):E2F4/5:DP1
type: GO_0003674
BFO_0000050: G0 and Early G1
directly activates: Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
directly activates: Control135
directly activates: Control136
label: Recruitment of HDAC1 by p130 (RBL2)

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
type: GO_0003674
BFO_0000050: G0 and Early G1

p107 (RBL1) binds CyclinE/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

p130 (RBL2) binds Cyclin E/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2
type: GO_0003674
BFO_0000050: G0 and Early G1

G0 and Early G1
type: GO_0008150