CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

MAP3K1
label: MAPKKK1
label: MEKK
label: MEKK1
label: UniProt:Q13233 MAP3K1

Recruitment of GRB2:SOS to p-5Y-LAT
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: SOS mediated nucleotide exchange of RAS (SHC)
directly activates: Catalysis446

Recruitment of GADS:SLP-76 to p-5Y-LAT
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: BiochemicalReaction1282
directly activates: Phosphorylation of SLP-76 by p-SYK
directly activates: Catalysis450
directly activates: Catalysis466

Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Recruitment of GADS:SLP-76 to p-5Y-LAT

SOS mediated nucleotide exchange of RAS (SHC)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: FCERI mediated MAPK activation
directly activates: RAF/MAP kinase cascade

p-RAF binds 14-3-3 beta/alpha
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Transient dissociation of 14-3-3 upon Ras binding

Transient dissociation of 14-3-3 upon Ras binding
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAS:RAF by 14-3-3

Stabilisation of RAS:RAF by 14-3-3
type: GO_0003674
BFO_0000050: RAF activation
directly activates: Stabilisation of RAF by further phosphorylation
directly activates: Catalysis447

Stabilisation of RAF by further phosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: RAF activation
directly activates: Activated RAF1 complex binds MEK

Phosphorylated human RAF1 binds to RAS:GTP complex
type: GO_0003674
BFO_0000050: RAF activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

Activated RAF1 complex binds MEK
type: GO_0003674
BFO_0000050: MEK activation
directly activates: RAF1 phosphorylates MEK1
directly activates: RAF1 phosphorylates MEK2
directly activates: Catalysis448
directly activates: Catalysis449

RAF1 phosphorylates MEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK1 binds ERK-1

RAF1 phosphorylates MEK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: RAF phosphorylates MEK
directly activates: MEK2 binds ERK-2

Phosphorylation of SHC by SYK kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: FCERI mediated MAPK activation
directly activates: Interaction of GRB2:SOS complex with p-SHC1

Interaction of GRB2:SOS complex with p-SHC1
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Recruitment of GRB2:SOS to p-5Y-LAT
directly activates: BiochemicalReaction1343

Phosphorylation of SLP-76 by p-SYK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: FCERI mediated MAPK activation
directly activates: Recruitment of VAV to p-SLP-76

Recruitment of VAV to p-SLP-76
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Phosphorylation and activation of VAV
directly activates: BiochemicalReaction1319

Phosphorylation and activation of VAV
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Activation of RAC1 by VAV
directly activates: Catalysis467

Activation of RAC1 by VAV
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: FCERI mediated MAPK activation
directly activates: Recruitment of PAK to the membrane by binding active RAC1

Recruitment of PAK to the membrane by binding active RAC1
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Autophosphorylation of PAK
directly activates: Catalysis468

Autophosphorylation of PAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Autophosphorylation and activation of MEKK1
directly activates: Catalysis469
directly activates: Control96

Autophosphorylation and activation of MEKK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAP3K1
type: GO_0004672
BFO_0000050: FCERI mediated MAPK activation
directly activates: Phosphorylation of MEK4 by MEKK1
directly activates: Phosphorylation of MEK7 by MEKK1
directly activates: Catalysis470
directly activates: Catalysis471

Phosphorylation of MEK4 by MEKK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAP3K1
type: GO_0004674
BFO_0000050: FCERI mediated MAPK activation

Phosphorylation of MEK7 by MEKK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAP3K1
type: GO_0004674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Phosphorylation of human JNKs by activated MKK4/MKK7
directly activates: Catalysis339

Phosphorylation of human JNKs by activated MKK4/MKK7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008545
BFO_0000050: FCERI mediated MAPK activation
directly activates: Activated human JNKs migrate to nucleoplasm

Activated human JNKs migrate to nucleoplasm
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation
directly activates: BiochemicalReaction916
directly activates: Activated JNKs phosphorylate c-JUN
directly activates: Catalysis357
directly activates: Catalysis358

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: BiochemicalReaction905
directly activates: BiochemicalReaction906
directly activates: BiochemicalReaction908
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

Activated JNKs phosphorylate c-JUN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004705
BFO_0000050: FCERI mediated MAPK activation
directly activates: BiochemicalReaction919
directly activates: Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

c-FOS activation by phospho ERK1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: FCERI mediated MAPK activation
directly activates: Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
type: GO_0003674
BFO_0000050: FCERI mediated MAPK activation

ERK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

RAF/MAP kinase cascade
type: GO_0008150
BFO_0000050: FCERI mediated MAPK activation

RAF activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

MEK activation
type: GO_0008150
BFO_0000050: RAF/MAP kinase cascade

RAF phosphorylates MEK
type: GO_0008150
BFO_0000050: MEK activation

FCERI mediated MAPK activation
type: GO_0008150