CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
MAP3K1
MAPKKK1
MEKK
MEKK1
UniProt:Q13233 MAP3K1
Recruitment of GRB2:SOS to p-5Y-LAT
Recruitment of GADS:SLP-76 to p-5Y-LAT
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
SOS mediated nucleotide exchange of RAS (SHC)
p-RAF binds 14-3-3 beta/alpha
Transient dissociation of 14-3-3 upon Ras binding
Stabilisation of RAS:RAF by 14-3-3
Stabilisation of RAF by further phosphorylation
Phosphorylated human RAF1 binds to RAS:GTP complex
Activated RAF1 complex binds MEK
RAF1 phosphorylates MEK1
RAF1 phosphorylates MEK2
Phosphorylation of SHC by SYK kinase
Interaction of GRB2:SOS complex with p-SHC1
Phosphorylation of SLP-76 by p-SYK
Recruitment of VAV to p-SLP-76
Phosphorylation and activation of VAV
Activation of RAC1 by VAV
Recruitment of PAK to the membrane by binding active RAC1
Autophosphorylation of PAK
Autophosphorylation and activation of MEKK1
Phosphorylation of MEK4 by MEKK1
Phosphorylation of MEK7 by MEKK1
Phosphorylation of human JNKs by activated MKK4/MKK7
Activated human JNKs migrate to nucleoplasm
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
Activated JNKs phosphorylate c-JUN
c-FOS activation by phospho ERK1/2
Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
ERK activation
ERK1 activation
ERK2 activation
RAF/MAP kinase cascade
RAF activation
MEK activation
RAF phosphorylates MEK
FCERI mediated MAPK activation